| Gene Information | |
|---|---|
| Gene Name | MGAM |
| Organism | Homo sapiens (Human) |
| Gene Length | 2753 |
| Protein Names | Maltase-glucoamylase (Alpha-1,4-glucosidase) (EC 3.2.1.20) |
| Target Name | intestinal maltase-glucoamylase |
| Target Type | Successful target |
| Gene Age | >4290 ( ENSG00000257335 ) 3 ( ENSG00000282607 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43451 |
| Gene Card | MGAM |
| Uniprot ID | O43451 |
| Pfam | PF01055; PF16863; PF00088 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000075191) |
| Ortholog in Animals | Alpaca_ MGAM ( ortholog_one2many ) Dog_ MGAM ( ortholog_one2one ) GuineaPig_ MGAM ( ortholog_one2one ) Macaque_ MGAM ( ortholog_one2one ) Mouse_ Mgam ( ortholog_one2one ) Pig_ MGAM ( ortholog_one2one ) Rat_ Mgam ( ortholog_one2one ) Rabbit_ MGAM ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MYORG, GANC, MGAM2, GAA, GANAB, SI |
| Tissue | duodenum, small.intestine, epididymis, small.intestine.Peyers.patch, whole.blood |
| Tissue Specificity | Broadly expressed. Highly expressed in small intestine. Expressed in granulocytes. {ECO:0000269|PubMed:24309898, ECO:0000269|PubMed:9446624}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2QLY (X-ray 2.00A ) 2QMJ (X-ray 1.90A ) 3CTT (X-ray 2.10A ) 3L4T (X-ray 1.90A ) 3L4U (X-ray 1.90A ) 3L4V (X-ray 2.10A ) 3L4W (X-ray 2.00A ) 3L4X (X-ray 1.90A ) 3L4Y (X-ray 1.80A ) 3L4Z (X-ray 2.00A ) 3TON (X-ray 2.95A ) 3TOP (X-ray 2.88A ) |
| DBSNP | rs2272330 rs10266732 rs2960746 rs9655651 |
| Subcellular location [CC] | Apical cell membrane; Single-pass type II membrane protein. Note=Brush border. {ECO:0000269|PubMed:3143729}. |
| Mouse PG classification | NA |
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