| Gene Information | |
|---|---|
| Gene Name | MFN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 757 |
| Protein Names | Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000116688 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O95140 |
| Gene Card | MFN2 |
| Uniprot ID | O95140 |
| Pfam | PF00350; PF04799 |
| In ASD | no |
| Allosteric Prediction | no (-0.344733925) |
| Ortholog in Animals | Alpaca_ MFN2 ( ortholog_one2one ) Dog_ MFN2 ( ortholog_one2one ) GuineaPig_ MFN2 ( ortholog_one2one ) Macaque_ MFN2 ( ortholog_one2one ) Mouse_ Mfn2 ( ortholog_one2one ) Pig_ MFN2 ( ortholog_one2one ) Rat_ Mfn2 ( ortholog_one2one ) Rabbit_ MFN2 ( ortholog_one2one ) |
| Ohnologs | MFN1 |
| Paralogs | MFN1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous; expressed at low level. Highly expressed in heart and kidney. {ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12759376}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6JFK (X-ray 2.00A ) 6JFL (X-ray 2.81A ) 6JFM (X-ray 2.09A ) |
| DBSNP | rs28940296 rs28940293 rs28940291 rs119103263 rs1553142699 rs119103266 rs387906990 rs28940295 rs755065651 rs119103264 rs28940294 rs119103261 rs387906991 rs119103265 rs1553144059 rs138382758 rs376925978 rs142271930 rs119103267 rs144860227 rs28940292 |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12499352, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:26214738}; Multi-pass membrane protein {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12499352, ECO:0000269|PubMed:23620051}. Note=Colocalizes with BAX during apoptosis. {ECO:0000269|PubMed:12499352}. |
| Mouse PG classification | LPG |
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