| Gene Information | |
|---|---|
| Gene Name | MFN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 741 |
| Protein Names | Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000171109 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8IWA4 |
| Gene Card | MFN1 |
| Uniprot ID | Q8IWA4 |
| Pfam | PF00350; PF04799 |
| In ASD | no |
| Allosteric Prediction | no (-0.565938939) |
| Ortholog in Animals | Alpaca_ MFN1 ( ortholog_one2one ) Dog_ MFN1 ( ortholog_one2one ) GuineaPig_ MFN1 ( ortholog_one2one ) Macaque_ MFN1 ( ortholog_one2one ) Mouse_ Mfn1 ( ortholog_one2one ) Pig_ MFN1 ( ortholog_one2one ) Rat_ Mfn1 ( ortholog_one2one ) Rabbit_ MFN1 ( ortholog_one2one ) |
| Ohnologs | MFN2 |
| Paralogs | MFN2 |
| Tissue | NA |
| Tissue Specificity | Detected in kidney and heart (at protein level) (PubMed:12759376). Ubiquitous (PubMed:11950885, PubMed:12759376). Expressed at slightly higher level in kidney and heart (PubMed:12759376). Isoform 2 may be overexpressed in some tumors, such as lung cancers (PubMed:11751411). {ECO:0000269|PubMed:11751411, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12759376}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 5GNR (X-ray 2.65A ) 5GNS (X-ray 2.70A ) 5GNT (X-ray 2.67A ) 5GNU (X-ray 4.11A ) 5GO4 (X-ray 2.20A ) 5GOE (X-ray 1.80A ) 5GOF (X-ray 1.60A ) 5GOM (X-ray 2.80A ) 5YEW (X-ray 3.20A ) |
| DBSNP | rs7637065 |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000269|PubMed:12759376, ECO:0000305|PubMed:27920125}; Multi-pass membrane protein {ECO:0000305|PubMed:12759376}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:11751411}. |
| Mouse PG classification | NA |
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