| Gene Information | |
|---|---|
| Gene Name | MFGE8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 387 |
| Protein Names | Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000140545 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q08431 |
| Gene Card | MFGE8 |
| Uniprot ID | Q08431 |
| Pfam | PF00008; PF00754 |
| In ASD | no |
| Allosteric Prediction | no (-0.084022032) |
| Ortholog in Animals | Alpaca_ MFGE8 ( ortholog_one2one ) Dog_ MFGE8 ( ortholog_one2one ) GuineaPig_ MFGE8 ( ortholog_one2one ) Macaque_ MFGE8 ( ortholog_one2one ) Mouse_ Mfge8 ( ortholog_one2one ) Pig_ MFGE8 ( ortholog_one2one ) Rat_ Mfge8 ( ortholog_one2one ) |
| Ohnologs | EDIL3 |
| Paralogs | CNTNAP3B, CNTNAP3, CNTNAP3C, CNTNAP4, PDGFD, ASTL, CNTNAP5, HEPH, MEP1A, NRXN2, CNTNAP2, MFRP, CUZD1, NETO2, TLL2, F5, PCOLCE, CP, NRP1, NRXN3, EDIL3, CNTNAP1, CUBN, MEP1B, NETO1, PCOLCE2, NRP2, HEPHL1, F8, TLL1, NRXN1, DCBLD2, PDGFC, CDCP2, BMP1 |
| Tissue | substantia.nigra |
| Tissue Specificity | Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs4945 rs1878326 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:19204935}; Peripheral membrane protein {ECO:0000269|PubMed:19204935}. Secreted {ECO:0000269|PubMed:19204935}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P79385}; Peripheral membrane protein {ECO:0000250|UniProtKB:P79385}. Note=Located in the acrosomal region of zona-pellucida bound sperm. {ECO:0000250|UniProtKB:P79385}. |
| Mouse PG classification | NA |
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