| Gene Information | |
|---|---|
| Gene Name | PYCARD |
| Organism | Homo sapiens (Human) |
| Gene Length | 195 |
| Protein Names | Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000103490 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9ULZ3 |
| Gene Card | PYCARD |
| Uniprot ID | Q9ULZ3 |
| Pfam | PF00619; PF02758 |
| In ASD | no |
| Allosteric Prediction | yes (0.293584751) |
| Ortholog in Animals | Alpaca_ PYCARD ( ortholog_one2one ) Dog_ PYCARD ( ortholog_one2one ) GuineaPig_ PYCARD ( ortholog_one2one ) Macaque_ PYCARD ( ortholog_one2one ) Mouse_ Pycard ( ortholog_one2one ) Pig_ PYCARD ( ortholog_one2one ) Rat_ Pycard ( ortholog_one2one ) Rabbit_ PYCARD ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CASP14, CASP8, CASP2, CASP6, CFLAR, CASP10, CARD18, CASP9, CASP1, CARD16, CASP5, CASP4, CASP3, CASP7, PYDC1, CASP12 |
| Tissue | NA |
| Tissue Specificity | Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Expressed in lung epithelial cells (at protein level) (PubMed:23229815). Detected in the leukemia cell lines HL-60 and U-937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and MOLT-4 lymphocytic leukemia cells. {ECO:0000269|PubMed:23229815}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.003490(Rat);0.046154(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1UCP (NMR - ) 2KN6 (NMR - ) 3J63 (EM 3.80A ) 5H8O (X-ray 4.21A ) 6K99 (EM 4.10A ) 6KI0 (X-ray 2.00A ) 6N1H (EM 3.17A ) 7E5B (X-ray 2.29A ) 7KEU (EM 3.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11103777, ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:19234215, ECO:0000269|PubMed:25847972}. Inflammasome {ECO:0000269|PubMed:12191486, ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:30674671, ECO:0000269|PubMed:34678144}. Endoplasmic reticulum {ECO:0000269|PubMed:21124315}. Mitochondrion {ECO:0000269|PubMed:14730312, ECO:0000269|PubMed:21124315}. Nucleus {ECO:0000269|PubMed:19234215, ECO:0000269|PubMed:25847972}. Note=Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures (PubMed:11103777, PubMed:12191486, PubMed:15030775). Upon NLRP3 inflammasome activation redistributes to the perinuclear space localizing to endoplasmic reticulum and mitochondria (PubMed:12191486, PubMed:15030775). Localized primarily to the nucleus in resting monocytes/macrophages and rapidly redistributed to the cytoplasm upon pathogen infection (PubMed:19234215). Localized to large cytoplasmic aggregate appearing as a speck containing AIM2, PYCARD, CASP8 and bacterial DNA after infection with Francisella tularensis (By similarity). {ECO:0000250|UniProtKB:Q9EPB4, ECO:0000269|PubMed:11103777, ECO:0000269|PubMed:12191486, ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:19234215}.; Golgi apparatus membrane {ECO:0000269|PubMed:23229815}. Note=(Microbial infection) Upon HRSV infection, the protein is mainly located in lipid rafts in the Golgi membrane. {ECO:0000269|PubMed:23229815}. |
| Mouse PG classification | NA |
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