| Gene Information | |
|---|---|
| Gene Name | METTL3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 580 |
| Protein Names | N6-adenosine-methyltransferase catalytic subunit (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000165819 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86U44 |
| Gene Card | METTL3 |
| Uniprot ID | Q86U44 |
| Pfam | PF05063 |
| In ASD | yes |
| Allosteric Prediction | no (-0.121495077) |
| Ortholog in Animals | Alpaca_ METTL3 ( ortholog_one2one ) Dog_ METTL3 ( ortholog_one2one ) GuineaPig_ METTL3 ( ortholog_one2one ) Macaque_ METTL3 ( ortholog_one2one ) Mouse_ Mettl3 ( ortholog_one2one ) Pig_ METTL3 ( ortholog_one2one ) Rat_ Mettl3 ( ortholog_one2one ) Rabbit_ METTL3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:9409616}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004990(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5IL0 (X-ray 1.88A ) 5IL1 (X-ray 1.71A ) 5IL2 (X-ray 1.61A ) 5K7M (X-ray 1.65A ) 5K7U (X-ray 1.70A ) 5K7W (X-ray 1.65A ) 5L6D (X-ray 1.85A ) 5L6E (X-ray 1.90A ) 5TEY (X-ray 1.80A ) 5YZ9 (Other - ) 6TTP (X-ray 2.00A ) 6TTT (X-ray 2.30A ) 6TTV (X-ray 2.14A ) 6TTW (X-ray 2.20A ) 6TTX (X-ray 2.00A ) 6TU1 (X-ray 2.31A ) 6Y4G (X-ray 1.90A ) 7ACD (X-ray 2.50A ) 7NHG (X-ray 2.50A ) 7NHH (X-ray 2.10A ) 7NHI (X-ray 1.85A ) 7NHJ (X-ray 2.16A ) 7NHV (X-ray 1.91A ) 7NI7 (X-ray 2.50A ) 7NI8 (X-ray 2.20A ) 7NI9 (X-ray 2.20A ) 7NIA (X-ray 2.30A ) 7NID (X-ray 2.30A ) 7O08 (X-ray 2.00A ) 7O09 (X-ray 1.80A ) 7O0L (X-ray 1.90A ) 7O0M (X-ray 2.39A ) 7O0P (X-ray 2.70A ) 7O0Q (X-ray 2.49A ) 7O0R (X-ray 2.30A ) 7O27 (X-ray 2.40A ) 7O28 (X-ray 2.47A ) 7O29 (X-ray 2.75A ) 7O2E (X-ray 2.50A ) 7O2F (X-ray 2.10A ) 7O2H (X-ray 2.50A ) 7O2I (X-ray 3.00A ) 7O2X (X-ray 2.80A ) 7OED (X-ray 2.00A ) 7OEE (X-ray 2.70A ) 7OEF (X-ray 2.03A ) 7OEG (X-ray 2.79A ) 7OEH (X-ray 2.01A ) 7OEI (X-ray 2.48A ) 7OEJ (X-ray 2.30A ) 7OEK (X-ray 1.90A ) 7OEL (X-ray 1.86A ) 7OEM (X-ray 2.20A ) 7OQL (X-ray 2.50A ) 7OQO (X-ray 3.35A ) 7OQP (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078}. Nucleus speckle {ECO:0000269|PubMed:9409616}. Cytoplasm {ECO:0000269|PubMed:27117702}. Note=Colocalizes with speckles in interphase nuclei, suggesting that it may be associated with nuclear pre-mRNA splicing components (PubMed:9409616). In response to ultraviolet irradiation, colocalizes to DNA damage sites however, it probably does not bind DNA but localizes in the vicinity of DNA damage sites (PubMed:28297716). {ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:9409616}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |