| Gene Information | |
|---|---|
| Gene Name | ENPEP |
| Organism | Homo sapiens (Human) |
| Gene Length | 957 |
| Protein Names | Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249) |
| Target Name | glutamyl aminopeptidase |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000138792 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q07075 |
| Gene Card | ENPEP |
| Uniprot ID | Q07075 |
| Pfam | PF11838; PF01433; PF17900 |
| In ASD | no |
| Allosteric Prediction | yes (0.278276194) |
| Ortholog in Animals | Alpaca_ ENPEP ( ortholog_one2one ) Dog_ ENPEP ( ortholog_one2one ) GuineaPig_ ENPEP ( ortholog_one2one ) Macaque_ ENPEP ( ortholog_one2one ) Mouse_ Enpep ( ortholog_one2one ) Pig_ ENPEP ( ortholog_one2one ) Rat_ Enpep ( ortholog_one2one ) Rabbit_ ENPEP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RNPEPL1, NPEPPS, ERAP1, AOPEP, LTA4H, TRHDE, LNPEP, LVRN, ANPEP, RNPEP, ERAP2 |
| Tissue | small.intestine.Peyers.patch |
| Tissue Specificity | Expressed in choriocarcinoma cancer cell lines (at protein level) (PubMed:10692253). Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues. {ECO:0000269|PubMed:10692253}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4KX7 (X-ray 2.15A ) 4KX8 (X-ray 2.40A ) 4KX9 (X-ray 2.25A ) 4KXA (X-ray 2.40A ) 4KXB (X-ray 2.40A ) 4KXC (X-ray 2.40A ) 4KXD (X-ray 2.15A ) |
| DBSNP | rs10004516 rs1126483 rs34949711 rs35812243 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10692253}; Single-pass type II membrane protein. |
| Mouse PG classification | NA |
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