| Gene Information | |
|---|---|
| Gene Name | ECI2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 394 |
| Protein Names | Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1) |
| Target Name | enoyl-coa delta isomerase 2, mitochondrial |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000198721 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O75521 |
| Gene Card | ECI2 |
| Uniprot ID | O75521 |
| Pfam | PF00887; PF00378 |
| In ASD | no |
| Allosteric Prediction | no (-0.559871036) |
| Ortholog in Animals | Alpaca_ ECI2 ( ortholog_one2one ) Dog_ ECI2 ( ortholog_one2one ) GuineaPig_ ECI2 ( ortholog_one2one ) Macaque_ ECI2 ( ortholog_one2one ) Mouse_ Eci2 ( ortholog_one2many ) Mouse_ Eci3 ( ortholog_one2many ) Pig_ ECI2 ( ortholog_one2one ) Rat_ Eci2 ( ortholog_one2many ) Rat_ Eci3 ( ortholog_one2many ) |
| Ohnologs | CDYL2 |
| Paralogs | DBI, ACBD4, ACBD7, ACBD5 |
| Tissue | NA |
| Tissue Specificity | Abundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells. {ECO:0000269|PubMed:10419495, ECO:0000269|PubMed:15217832}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001790(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2CQU (NMR - ) 2F6Q (X-ray 1.95A ) 4U18 (X-ray 2.64A ) 4U19 (X-ray 1.88A ) 4U1A (X-ray 2.85A ) |
| DBSNP | rs3177253 rs7166 |
| Subcellular location [CC] | [Isoform 1]: Mitochondrion {ECO:0000250|UniProtKB:Q5XIC0}.; [Isoform 2]: Peroxisome matrix {ECO:0000269|PubMed:10419495}. |
| Mouse PG classification | NA |
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