| Gene Information | |
|---|---|
| Gene Name | METAP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 478 |
| Protein Names | Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) |
| Target Name | methionine aminopeptidase 2 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000111142 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P50579 |
| Gene Card | METAP2 |
| Uniprot ID | P50579 |
| Pfam | PF00557 |
| In ASD | no |
| Allosteric Prediction | yes (0.694348888) |
| Ortholog in Animals | Alpaca_ METAP2 ( ortholog_one2one ) Dog_ METAP2 ( ortholog_one2one ) GuineaPig_ METAP2 ( ortholog_one2one ) Macaque_ METAP2 ( ortholog_one2one ) Mouse_ Metap2 ( ortholog_one2one ) Pig_ METAP2 ( ortholog_one2one ) Rabbit_ METAP2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | XPNPEP1, METAP1D, PA2G4, XPNPEP2, METAP1, XPNPEP3, PEPD |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1B59 (X-ray 1.80A ) 1B6A (X-ray 1.60A ) 1BN5 (X-ray 1.80A ) 1BOA (X-ray 1.80A ) 1KQ0 (X-ray 2.00A ) 1KQ9 (X-ray 1.90A ) 1QZY (X-ray 1.60A ) 1R58 (X-ray 1.90A ) 1R5G (X-ray 2.00A ) 1R5H (X-ray 2.40A ) 1YW7 (X-ray 1.85A ) 1YW8 (X-ray 2.65A ) 1YW9 (X-ray 1.64A ) 2ADU (X-ray 1.90A ) 2EA2 (X-ray 2.50A ) 2EA4 (X-ray 2.35A ) 2GA2 (X-ray 1.95A ) 2OAZ (X-ray 1.90A ) 5CLS (X-ray 1.75A ) 5D6E (X-ray 1.49A ) 5D6F (X-ray 1.55A ) 5JFR (X-ray 1.60A ) 5JHU (X-ray 1.80A ) 5JI6 (X-ray 2.15A ) 5LYW (X-ray 1.69A ) 5LYX (X-ray 1.90A ) 6QED (X-ray 1.80A ) 6QEF (X-ray 1.79A ) 6QEG (X-ray 2.08A ) 6QEH (X-ray 2.17A ) 6QEI (X-ray 1.80A ) 6QEJ (X-ray 1.62A ) 7A12 (X-ray 2.00A ) 7A13 (X-ray 2.04A ) 7A14 (X-ray 2.14A ) 7A15 (X-ray 2.15A ) 7A16 (X-ray 1.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:21537465}. Note=About 30% of expressed METAP2 associates with polysomes. |
| Mouse PG classification | NA |
| click here to return to the previous page | |