| Gene Information | |
|---|---|
| Gene Name | PTPN11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 593 |
| Protein Names | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) |
| Target Name | tyrosine-protein phosphatase non-receptor type 11 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000179295 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q06124 |
| Gene Card | PTPN11 |
| Uniprot ID | Q06124 |
| Pfam | PF00017; PF00102 |
| In ASD | yes |
| Allosteric Prediction | yes (1.408848181) |
| Ortholog in Animals | Alpaca_ PTPN11 ( ortholog_one2one ) Alpaca_ PTPN11 ( ortholog_one2many ) Dog_ PTPN11 ( ortholog_one2one ) GuineaPig_ PTPN11 ( ortholog_one2one ) Macaque_ PTPN11 ( ortholog_one2one ) Mouse_ Ptpn11 ( ortholog_one2one ) Pig_ PTPN11 ( ortholog_one2one ) Rat_ Ptpn11 ( ortholog_one2one ) Rabbit_ PTPN11 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest levels in heart, brain, and skeletal muscle. {ECO:0000269|PubMed:1280823, ECO:0000269|PubMed:7681589, ECO:0000269|PubMed:8216283}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.036735(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2SHP (X-ray 2.00A ) 3B7O (X-ray 1.60A ) 3MOW (X-ray 2.30A ) 3O5X (X-ray 2.00A ) 3TKZ (X-ray 1.80A ) 3TL0 (X-ray 2.05A ) 3ZM0 (X-ray 1.50A ) 3ZM1 (X-ray 1.40A ) 3ZM2 (X-ray 1.50A ) 3ZM3 (X-ray 1.50A ) 4DGP (X-ray 2.30A ) 4DGX (X-ray 2.30A ) 4GWF (X-ray 2.10A ) 4H1O (X-ray 2.20A ) 4H34 (X-ray 2.70A ) 4JE4 (X-ray 2.31A ) 4JEG (X-ray 2.30A ) 4JMG (X-ray 1.40A ) 4NWF (X-ray 2.10A ) 4NWG (X-ray 2.45A ) 4OHD (X-ray 2.70A ) 4OHE (X-ray 2.51A ) 4OHH (X-ray 2.70A ) 4OHI (X-ray 2.20A ) 4OHL (X-ray 2.40A ) 4PVG (X-ray 2.40A ) 4QSY (X-ray 2.10A ) 4RDD (X-ray 1.60A ) 5BK8 (X-ray 2.25A ) 5DF6 (X-ray 1.78A ) 5EHP (X-ray 1.85A ) 5EHR (X-ray 1.70A ) 5I6V (X-ray 1.87A ) 5IBM (X-ray 2.18A ) 5IBS (X-ray 2.32A ) 5X7B (X-ray 2.45A ) 5X94 (X-ray 2.60A ) 5XZR (X-ray 2.80A ) 6ATD (X-ray 2.50A ) 6BMR (X-ray 2.21A ) 6BMU (X-ray 2.12A ) 6BMV (X-ray 2.05A ) 6BMW (X-ray 2.10A ) 6BMX (X-ray 2.42A ) 6BMY (X-ray 2.09A ) 6BN5 (X-ray 2.22A ) 6CMP (X-ray 1.80A ) 6CMQ (X-ray 2.90A ) 6CMR (X-ray 2.21A ) 6CMS (X-ray 2.68A ) 6CRF (X-ray 2.62A ) 6CRG (X-ray 2.75A ) 6MD7 (X-ray 1.96A ) 6MD9 (X-ray 2.12A ) 6MDA (X-ray 2.21A ) 6MDB (X-ray 2.34A ) 6MDC (X-ray 2.14A ) 6MDD (X-ray 2.05A ) 6R5G (NMR - ) 6WU8 (X-ray 2.40A ) 7EMN (X-ray 3.00A ) 7JVM (X-ray 2.17A ) 7JVN (X-ray 1.92A ) 7R75 (X-ray 2.83A ) 7R7D (X-ray 2.60A ) 7R7I (X-ray 2.85A ) 7R7L (X-ray 3.00A ) 7RCT (X-ray 1.80A ) 7VXG (X-ray 2.10A ) |
| DBSNP | rs267606990 rs397507501 rs397507506 rs886043790 rs397507509 rs397507509 rs121918461 rs397507510 rs121918461 rs397507510 rs121918460 rs121918459 rs397507511 rs397507511 rs397507512 rs121918454 rs121918453 rs121918453 rs121918454 rs121918462 rs121918465 rs397507514 rs121918465 rs121918464 rs121918465 rs121918466 rs397507517 rs397507520 rs397507523 rs397507525 rs765642157 rs397507526 rs376607329 rs121918456 rs121918456 rs397507529 rs397507531 rs121918463 rs28933386 rs121918455 rs201787206 rs121918467 rs121918468 rs121918469 rs121918457 rs397507539 rs397507542 rs397507541 rs397507543 rs121918458 rs397507546 rs397507545 rs397507547 rs397509345 rs397507549 rs121918470 rs397516797 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:26742426}. Nucleus {ECO:0000269|PubMed:26742426}. |
| Mouse PG classification | NA |
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