| Gene Information | |
|---|---|
| Gene Name | MET |
| Organism | Homo sapiens (Human) |
| Gene Length | 1390 |
| Protein Names | Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) |
| Target Name | hepatocyte growth factor receptor |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000105976 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P08581 |
| Gene Card | MET |
| Uniprot ID | P08581 |
| Pfam | PF07714; PF01437; PF01403; PF01833 |
| In ASD | yes |
| Allosteric Prediction | yes (1.354897132) |
| Ortholog in Animals | Alpaca_ MET ( ortholog_one2one ) Dog_ MET ( ortholog_one2one ) GuineaPig_ MET ( ortholog_one2one ) Macaque_ MET ( ortholog_one2one ) Mouse_ Met ( ortholog_one2one ) Pig_ MET ( ortholog_one2one ) Rat_ Met ( ortholog_one2one ) Rabbit_ MET ( ortholog_one2one ) |
| Ohnologs | MST1R |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1 |
| Tissue | NA |
| Tissue Specificity | Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain. Expressed in metaphyseal bone (at protein level) (PubMed:26637977). {ECO:0000269|PubMed:1719465, ECO:0000269|PubMed:1917129, ECO:0000269|PubMed:26637977}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1FYR (X-ray 2.40A ) 1R0P (X-ray 1.80A ) 1R1W (X-ray 1.80A ) 1SHY (X-ray 3.22A ) 1SSL (NMR - ) 2G15 (X-ray 2.15A ) 2RFN (X-ray 2.50A ) 2RFS (X-ray 2.20A ) 2UZX (X-ray 2.80A ) 2UZY (X-ray 4.00A ) 2WD1 (X-ray 2.00A ) 2WGJ (X-ray 2.00A ) 2WKM (X-ray 2.20A ) 3A4P (X-ray 2.54A ) 3BUX (X-ray 1.35A ) 3C1X (X-ray 2.17A ) 3CCN (X-ray 1.90A ) 3CD8 (X-ray 2.00A ) 3CE3 (X-ray 2.40A ) 3CTH (X-ray 2.30A ) 3CTJ (X-ray 2.50A ) 3DKC (X-ray 1.52A ) 3DKF (X-ray 1.80A ) 3DKG (X-ray 1.91A ) 3EFJ (X-ray 2.60A ) 3EFK (X-ray 2.20A ) 3F66 (X-ray 1.40A ) 3F82 (X-ray 2.50A ) 3I5N (X-ray 2.00A ) 3L8V (X-ray 2.40A ) 3LQ8 (X-ray 2.02A ) 3Q6U (X-ray 1.60A ) 3Q6W (X-ray 1.75A ) 3QTI (X-ray 2.00A ) 3R7O (X-ray 2.30A ) 3RHK (X-ray 1.94A ) 3U6H (X-ray 2.00A ) 3U6I (X-ray 2.10A ) 3VW8 (X-ray 2.10A ) 3ZBX (X-ray 2.20A ) 3ZC5 (X-ray 2.20A ) 3ZCL (X-ray 1.40A ) 3ZXZ (X-ray 1.80A ) 3ZZE (X-ray 1.87A ) 4AOI (X-ray 1.90A ) 4AP7 (X-ray 1.80A ) 4DEG (X-ray 2.00A ) 4DEH (X-ray 2.00A ) 4DEI (X-ray 2.05A ) 4EEV (X-ray 1.80A ) 4GG5 (X-ray 2.42A ) 4GG7 (X-ray 2.27A ) 4IWD (X-ray 1.99A ) 4K3J (X-ray 2.80A ) 4KNB (X-ray 2.40A ) 4MXC (X-ray 1.63A ) 4O3T (X-ray 2.99A ) 4O3U (X-ray 3.04A ) 4R1V (X-ray 1.20A ) 4R1Y (X-ray 2.00A ) 4XMO (X-ray 1.75A ) 4XYF (X-ray 1.85A ) 5DG5 (X-ray 2.60A ) 5EOB (X-ray 1.75A ) 5EYC (X-ray 1.80A ) 5EYD (X-ray 1.85A ) 5HLW (X-ray 1.97A ) 5HNI (X-ray 1.71A ) 5HO6 (X-ray 1.97A ) 5HOA (X-ray 2.14A ) 5HOR (X-ray 2.20A ) 5HTI (X-ray 1.66A ) 5LSP (X-ray 2.60A ) 5T3Q (X-ray 2.00A ) 5UAB (X-ray 1.90A ) 5UAD (X-ray 2.25A ) 5YA5 (X-ray 1.89A ) 6GCU (X-ray 6.00A ) 6I04 (X-ray 3.10A ) 6SD9 (X-ray 2.35A ) 6SDC (X-ray 1.67A ) 6SDD (X-ray 1.93A ) 6SDE (X-ray 2.49A ) 6UBW (X-ray 2.00A ) 6WVZ (X-ray 3.10A ) 7B3Q (X-ray 1.75A ) 7B3T (X-ray 2.23A ) 7B3V (X-ray 1.93A ) 7B3W (X-ray 2.02A ) 7B3Z (X-ray 1.80A ) 7B40 (X-ray 1.76A ) 7B41 (X-ray 1.97A ) 7B42 (X-ray 1.80A ) 7B43 (X-ray 1.87A ) 7B44 (X-ray 1.76A ) 7MO7 (EM 4.80A ) 7MO8 (EM 4.50A ) 7MO9 (EM 4.00A ) 7MOA (EM 4.90A ) 7MOB (EM 5.00A ) 7V3R (X-ray 1.70A ) 7V3S (X-ray 1.90A ) 8AN8 (X-ray 2.39A ) 8ANS (X-ray 2.01A ) |
| DBSNP | rs35469582 rs1436957498 rs56311081 rs55985569 rs34349517 rs35225896 rs35776110 rs776693512 rs33917957 rs752055485 rs771333219 rs794728016 rs34589476 rs768678989 rs56391007 rs786202724 rs121913243 rs121913244 rs121913668 rs121913675 rs121913669 rs121913673 rs121913670 rs121913671 rs121913671 rs121913246 rs121913247 rs121913677 rs121913676 rs121913245 rs1263785859 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted. |
| Mouse PG classification | NA |
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