| Gene Information | |
|---|---|
| Gene Name | AFG3L2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 797 |
| Protein Names | AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein) |
| Target Name | afg3-like protein 2 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000141385 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9Y4W6 |
| Gene Card | AFG3L2 |
| Uniprot ID | Q9Y4W6 |
| Pfam | PF00004; PF17862; PF06480; PF01434 |
| In ASD | no |
| Allosteric Prediction | no (-0.130112243) |
| Ortholog in Animals | Alpaca_ AFG3L2 ( ortholog_one2one ) Dog_ AFG3L2 ( ortholog_one2one ) GuineaPig_ AFG3L2 ( ortholog_one2one ) Macaque_ AFG3L2 ( ortholog_one2one ) Mouse_ Afg3l2 ( ortholog_one2one ) Pig_ AFG3L2 ( ortholog_one2one ) Rat_ Afg3l2 ( ortholog_one2one ) Rabbit_ AFG3L2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SPG7, YME1L1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highly expressed in the cerebellar Purkinje cells. {ECO:0000269|PubMed:20208537}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.006483(Mouse);0.002755(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2LNA (NMR - ) 6NYY (EM 3.00A ) |
| DBSNP | rs755893615 rs151344512 rs912546325 rs1020764190 rs773240455 rs387906889 rs1226952405 rs151344513 rs151344515 rs151344515 rs151344514 rs151344518 rs151344517 rs1598820860 rs151344520 rs151344521 rs151344522 rs151344523 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:10395799, ECO:0000269|PubMed:22354088}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8JZQ2}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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