| Gene Information | |
|---|---|
| Gene Name | APOBR |
| Organism | Homo sapiens (Human) |
| Gene Length | 1097 |
| Protein Names | Apolipoprotein B receptor (Apolipoprotein B-100 receptor) (Apolipoprotein B-48 receptor) (Apolipoprotein B48 receptor) (apoB-48R) |
| Target Name | apolipoprotein b receptor |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000184730 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q0VD83 |
| Gene Card | APOBR |
| Uniprot ID | Q0VD83 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.595289534) |
| Ortholog in Animals | Macaque_ APOBR ( ortholog_one2one ) Mouse_ Apobr ( ortholog_one2one ) Rat_ Apobr ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | sigmoid.colon, spleen, whole.blood |
| Tissue Specificity | Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells. {ECO:0000269|PubMed:10191299, ECO:0000269|PubMed:10852956}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs148114931 rs180743 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10191299, ECO:0000269|PubMed:7619811}; Peripheral membrane protein {ECO:0000269|PubMed:10191299, ECO:0000269|PubMed:7619811}. Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein. |
| Mouse PG classification | NA |
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