| Gene Information | |
|---|---|
| Gene Name | MEP50 |
| Organism | Homo sapiens (Human) |
| Gene Length | 342 |
| Protein Names | Methylosome protein 50 (MEP-50) (Androgen receptor cofactor p44) (WD repeat-containing protein 77) (p44/Mep50) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BQA1 |
| Gene Card | WDR77 |
| Uniprot ID | Q9BQA1 |
| Pfam | PF00400 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors. {ECO:0000269|PubMed:12972618, ECO:0000269|PubMed:17437848}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4GQB (X-ray 2.06A ) 4X60 (X-ray 2.35A ) 4X61 (X-ray 2.85A ) 4X63 (X-ray 3.05A ) 5C9Z (X-ray 2.36A ) 5EMJ (X-ray 2.27A ) 5EMK (X-ray 2.52A ) 5EML (X-ray 2.39A ) 5EMM (X-ray 2.37A ) 5FA5 (X-ray 2.34A ) 6CKC (X-ray 2.80A ) 6K1S (X-ray 2.60A ) 6RLL (X-ray 2.22A ) 6RLQ (X-ray 2.53A ) 6UGH (EM 3.40A ) 6UXX (X-ray 2.69A ) 6UXY (X-ray 2.57A ) 6V0N (X-ray 2.11A ) 6V0O (X-ray 2.86A ) 6V0P (X-ray 1.88A ) 7BO7 (X-ray 2.83A ) 7KIB (X-ray 2.52A ) 7KIC (X-ray 2.43A ) 7KID (X-ray 2.50A ) 7L1G (X-ray 2.47A ) 7M05 (EM 2.39A ) 7MX7 (X-ray 2.49A ) 7MXA (X-ray 2.71A ) 7MXC (X-ray 2.41A ) 7MXG (X-ray 2.40A ) 7MXN (X-ray 2.55A ) 7S0U (X-ray 2.01A ) 7S1P (X-ray 2.21A ) 7S1Q (X-ray 2.78A ) 7S1R (X-ray 2.10A ) 7S1S (X-ray 2.62A ) 7SER (X-ray 2.14A ) 7SES (X-ray 2.50A ) 7U30 (X-ray 2.60A ) 7UOH (X-ray 2.70A ) |
| DBSNP | rs7416672 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17437848, ECO:0000269|PubMed:21081503}. Cytoplasm {ECO:0000269|PubMed:17437848, ECO:0000269|PubMed:21081503}. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors (PubMed:17437848). {ECO:0000269|PubMed:17437848}. |
| Mouse PG classification | NA |
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