| Gene Information | |
|---|---|
| Gene Name | MEP1B |
| Organism | Homo sapiens (Human) |
| Gene Length | 701 |
| Protein Names | Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta) (PABA peptide hydrolase) (PPH beta) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000141434 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q16820 |
| Gene Card | MEP1B |
| Uniprot ID | Q16820 |
| Pfam | PF01400; PF00629 |
| In ASD | no |
| Allosteric Prediction | yes (0.042918252) |
| Ortholog in Animals | Alpaca_ MEP1B ( ortholog_one2one ) Dog_ MEP1B ( ortholog_one2one ) GuineaPig_ MEP1B ( ortholog_one2one ) Macaque_ MEP1B ( ortholog_one2one ) Mouse_ Mep1b ( ortholog_one2one ) Pig_ MEP1B ( ortholog_one2one ) Rat_ Mep1b ( ortholog_one2one ) Rabbit_ MEP1B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CNTNAP3B, CNTNAP3, CNTNAP3C, CNTNAP4, PDGFD, ASTL, CNTNAP5, HEPH, MEP1A, NRXN2, CNTNAP2, MFRP, CUZD1, NETO2, TLL2, F5, PCOLCE, CP, NRP1, NRXN3, EDIL3, CNTNAP1, CUBN, NETO1, MFGE8, PCOLCE2, NRP2, HEPHL1, F8, TLL1, NRXN1, DCBLD2, PDGFC, CDCP2, BMP1 |
| Tissue | duodenum, small.intestine, small.intestine.Peyers.patch |
| Tissue Specificity | The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells. {ECO:0000269|PubMed:12387727}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4GWM (X-ray 1.85A ) 4GWN (X-ray 3.00A ) 7AQ1 (X-ray 2.41A ) 7AUW (X-ray 2.80A ) |
| DBSNP | rs9959396 rs616114 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:22988105}; Single-pass type I membrane protein. Secreted {ECO:0000269|PubMed:10215852}. Note=Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17. {ECO:0000269|PubMed:22988105}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |