| Gene Information | |
|---|---|
| Gene Name | MELTF |
| Organism | Homo sapiens (Human) |
| Gene Length | 738 |
| Protein Names | Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228) |
| Target Name | melanotransferrin |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000163975 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P08582 |
| Gene Card | MELTF |
| Uniprot ID | P08582 |
| Pfam | PF00405 |
| In ASD | no |
| Allosteric Prediction | no (-0.308911052) |
| Ortholog in Animals | Alpaca_ MELTF ( ortholog_one2one ) Dog_ MELTF ( ortholog_one2one ) GuineaPig_ MELTF ( ortholog_one2one ) Macaque_ MELTF ( ortholog_one2one ) Mouse_ Meltf ( ortholog_one2one ) Pig_ MELTF ( ortholog_one2one ) Rat_ Meltf ( ortholog_one2one ) Rabbit_ MELTF ( ortholog_one2one ) |
| Ohnologs | LTF, TF |
| Paralogs | LTF, TF, SRPRB |
| Tissue | parotid.gland, submandibular.gland |
| Tissue Specificity | Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6XR0 (X-ray 3.06A ) |
| DBSNP | rs2276790 rs17129219 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor. |
| Mouse PG classification | NA |
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