| Gene Information | |
|---|---|
| Gene Name | MEL |
| Organism | Homo sapiens (Human) |
| Gene Length | 207 |
| Protein Names | Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P61006 |
| Gene Card | RAB8A |
| Uniprot ID | P61006 |
| Pfam | PF00071 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3QBT (X-ray 2.00A ) 3TNF (X-ray 2.50A ) 4LHV (X-ray 1.95A ) 4LHW (X-ray 1.55A ) 4LHX (X-ray 3.05A ) 4LHY (X-ray 3.10A ) 4LHZ (X-ray 3.20A ) 4LI0 (X-ray 3.30A ) 5SZI (X-ray 2.85A ) 6RIR (X-ray 1.77A ) 6SQ2 (X-ray 1.68A ) 6STF (X-ray 2.40A ) 6STG (X-ray 2.50A ) 6WHE (X-ray 1.73A ) 6YX5 (X-ray 2.14A ) 6ZSI (X-ray 1.91A ) 6ZSJ (X-ray 2.00A ) 7BWT (X-ray 2.30A ) 7LWB (X-ray 1.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:26824392, ECO:0000305|PubMed:12221131}; Lipid-anchor {ECO:0000305|PubMed:12221131}; Cytoplasmic side {ECO:0000305|PubMed:12221131}. Golgi apparatus {ECO:0000269|PubMed:15837803}. Recycling endosome membrane {ECO:0000269|PubMed:19864458}. Cell projection, cilium {ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:29125462}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q92930}; Lipid-anchor {ECO:0000250|UniProtKB:Q92930}; Cytoplasmic side {ECO:0000250|UniProtKB:Q92930}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:P55258}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:30398148}. Midbody {ECO:0000269|PubMed:22159412}. Cytoplasm {ECO:0000269|PubMed:26824392}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:30398148}. Note=Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane (PubMed:15837803). In the GDP-bound form, present in the perinuclear region (PubMed:12221131). Shows a polarized distribution to distal regions of cell protrusions in the GTP-bound form (PubMed:12221131). Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297). Localizes to tubular recycling endosome (PubMed:19864458). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). Non-phosphorylated RAB8A predominantly localizes to the cytoplasm whereas phosphorylated RAB8A localizes to the membrane (PubMed:26824392, PubMed:29125462, PubMed:30398148). {ECO:0000269|PubMed:12221131, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:30398148}. |
| Mouse PG classification | NA |
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