| Gene Information | |
|---|---|
| Gene Name | TSSK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 358 |
| Protein Names | Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (DiGeorge syndrome protein G) (DGS-G) (Serine/threonine-protein kinase 22B) |
| Target Name | testis-specific serine kinase 2 |
| Target Type | Literature-reported target |
| Gene Age | 424 ( ENSG00000206203 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96PF2 |
| Gene Card | TSSK2 |
| Uniprot ID | Q96PF2 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.392778897) |
| Ortholog in Animals | Alpaca_ TSSK2 ( ortholog_one2one ) Dog_ TSSK2 ( ortholog_one2one ) Macaque_ TSSK2 ( ortholog_one2one ) Mouse_ Tssk2 ( ortholog_one2one ) Pig_ TSSK2 ( ortholog_one2one ) Rabbit_ TSSK2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TSSK6, SNRK, SIK2, SIK3, NIM1K, NUAK2, TSSK4, SIK1, PRKAA2, BRSK2, NUAK1, BRSK1, HUNK, PRKAA1, TSSK1B, MELK, TSSK3 |
| Tissue | testis |
| Tissue Specificity | Testis-specific. Present in mature spermatozoa (at protein level). {ECO:0000269|PubMed:15044604, ECO:0000269|PubMed:18533145, ECO:0000269|PubMed:20729278}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3747052 rs35532431 rs56279111 rs35048893 rs8140743 rs1052763 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:18495105}. Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment (By similarity). In spermatids, concentrates in centrioles during flagellogenesis. {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |