Gene Information
Gene NameSLC17A5
OrganismHomo sapiens (Human)
Gene Length495
Protein NamesSialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000119899 )
Evolutionary StageCellular_organisms
AlphaFoldDBQ9NRA2
Gene CardSLC17A5
Uniprot IDQ9NRA2
PfamPF07690
In ASDno
Allosteric Predictionyes (0.342308196)
Ortholog in AnimalsAlpaca_ SLC17A5 ( ortholog_one2one )
Dog_ SLC17A5 ( ortholog_one2one )
GuineaPig_ SLC17A5 ( ortholog_one2one )
Macaque_ SLC17A5 ( ortholog_one2one )
Mouse_ Slc17a5 ( ortholog_one2one )
Pig_ SLC17A5 ( ortholog_one2one )
Rabbit_ SLC17A5 ( ortholog_one2one )
OhnologsNA
ParalogsSLC17A8, SLC37A4, SLC17A3, SLC17A6, SLC17A7, SLC17A9, SLC17A2, SLC37A1, SLC17A1, SLC37A3, SLC37A2, SLC17A4
TissueNA
Tissue SpecificityFound in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues. {ECO:0000269|PubMed:10581036, ECO:0000269|PubMed:11751519}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs80338794  rs80338795  rs119491109  rs16883930  rs119491110  rs777862172 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:22778404};
Multi-pass membrane protein {ECO:0000269|PubMed:22778404}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:21781115};
Multi-pass membrane protein {ECO:0000269|PubMed:21781115}. Lysosome membrane {ECO:0000269|PubMed:17897319};
Multi-pass membrane protein {ECO:0000269|PubMed:17897319}.
Mouse PG classificationLPG
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