| Gene Information | |
|---|---|
| Gene Name | FCRL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 429 |
| Protein Names | Fc receptor-like protein 1 (FcR-like protein 1) (FcRL1) (Fc receptor homolog 1) (FcRH1) (IFGP family protein 1) (hIFGP1) (Immune receptor translocation-associated protein 5) (CD antigen CD307a) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000163534 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q96LA6 |
| Gene Card | FCRL1 |
| Uniprot ID | Q96LA6 |
| Pfam | PF13895; PF17736 |
| In ASD | no |
| Allosteric Prediction | no (-1.263191536) |
| Ortholog in Animals | Dog_ FCRL1 ( ortholog_one2one ) GuineaPig_ FCRL1 ( ortholog_one2one ) Macaque_ FCRL1 ( ortholog_one2one ) Mouse_ Fcrl1 ( ortholog_one2one ) Pig_ FCRL1 ( ortholog_one2one ) Rat_ Fcrl6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PECAM1, C17orf99, FCGR3B, FCRL5, FCRLA, FCGR2A, FCRLB, FCRL4, MILR1, FCGR2B, FCGR3A, FCGR1A, FCER1A, FCGR2C, FCRL6, FCRL2, FCRL3 |
| Tissue | appendix, lymph.node, spleen, tonsil |
| Tissue Specificity | Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level). {ECO:0000269|PubMed:11493702, ECO:0000269|PubMed:11929751, ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12078586 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}. |
| Mouse PG classification | NA |
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