| Gene Information | |
|---|---|
| Gene Name | MEGF10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1140 |
| Protein Names | Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000145794 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96KG7 |
| Gene Card | MEGF10 |
| Uniprot ID | Q96KG7 |
| Pfam | PF12661; PF00053 |
| In ASD | no |
| Allosteric Prediction | no (-0.762626345) |
| Ortholog in Animals | Alpaca_ MEGF10 ( ortholog_one2one ) Dog_ MEGF10 ( ortholog_one2one ) GuineaPig_ MEGF10 ( ortholog_one2one ) Macaque_ MEGF10 ( ortholog_one2one ) Mouse_ Megf10 ( ortholog_one2one ) Pig_ MEGF10 ( ortholog_one2one ) Rat_ Megf10 ( ortholog_one2one ) Rabbit_ MEGF10 ( ortholog_one2one ) |
| Ohnologs | MEGF11, PEAR1 |
| Paralogs | MEGF11, MEGF6, GAS6 |
| Tissue | brain |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs387907074 rs3812054 rs387907073 rs387907072 rs13183625 rs1433266858 rs17164935 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:27170117}; Single-pass type I membrane protein. Cell projection, phagocytic cup {ECO:0000269|PubMed:17205124}. Note=Enriched at the sites of contact with apoptotic thymocyte cells (PubMed:17205124). Forms an irregular, mosaic-like adhesion pattern in region of the cell surface that becomes firmely fixed to the substrate. Expressed at the cell surface in clusters around cell corpses during engulfment. During the engulfment of apoptotic thymocytes, recruited at the bottom of the forming phagocytic cup (PubMed:17498693). Colocalizes with ABCA1 in absence of any phagocytic challenge (PubMed:17205124). Does not localize within lamellipodia (PubMed:17498693). Does not localize with MEGF11 (PubMed:17498693). {ECO:0000269|PubMed:17205124, ECO:0000269|PubMed:17498693}. |
| Mouse PG classification | NA |
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