| Gene Information | |
|---|---|
| Gene Name | MEF2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 507 |
| Protein Names | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000068305 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q02078 |
| Gene Card | MEF2A |
| Uniprot ID | Q02078 |
| Pfam | PF12347; PF00319 |
| In ASD | no |
| Allosteric Prediction | no (-0.651335772) |
| Ortholog in Animals | Alpaca_ MEF2A ( ortholog_one2one ) Dog_ MEF2A ( ortholog_one2one ) GuineaPig_ MEF2A ( ortholog_one2one ) Macaque_ MEF2A ( ortholog_one2one ) Mouse_ Mef2a ( ortholog_one2one ) Pig_ MEF2A ( ortholog_one2one ) Rat_ Mef2a ( ortholog_one2one ) Rabbit_ MEF2A ( ortholog_one2one ) |
| Ohnologs | MEF2C, MEF2D |
| Paralogs | MEF2B, MEF2D, SRF, MEF2C |
| Tissue | NA |
| Tissue Specificity | Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined. {ECO:0000269|PubMed:1516833, ECO:0000269|PubMed:1748287}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.047059(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1C7U (NMR - ) 1EGW (X-ray 1.50A ) 1LEW (X-ray 2.30A ) 3KOV (X-ray 2.90A ) 3MU6 (X-ray 2.43A ) 3P57 (X-ray 2.19A ) 6BYY (X-ray 2.30A ) 6BZ1 (X-ray 2.97A ) |
| DBSNP | rs121918530 rs121918529 rs121918531 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:16563226}. |
| Mouse PG classification | NA |
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