Gene Information
Gene NameENPP3
OrganismHomo sapiens (Human)
Gene Length875
Protein NamesEctonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (NPP3) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (CD antigen CD203c) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]
Target Namephosphodiesterase i beta
Target TypeClinical trial target
Gene Age1488 ( ENSG00000154269 )
Evolutionary StageEumetazoa
AlphaFoldDBO14638
Gene CardENPP3
Uniprot IDO14638
PfamPF01223; PF01663; PF01033
In ASDno
Allosteric Predictionyes (0.705818103)
Ortholog in AnimalsAlpaca_ ENPP3 ( ortholog_one2one )
Dog_ ENPP3 ( ortholog_one2one )
GuineaPig_ ENPP3 ( ortholog_one2one )
Macaque_ ENPP3 ( ortholog_one2one )
Mouse_ Enpp3 ( ortholog_one2one )
Pig_ ENPP3 ( ortholog_one2one )
Rat_ Enpp3 ( ortholog_one2one )
Rabbit_ ENPP3 ( ortholog_one2one )
OhnologsENPP2
ParalogsENPP2, ENPP4, ENPP5, ENPP6, ENPP7, ENPP1
Tissuesmall.intestine, seminal.vesicle
Tissue SpecificityDetected on bile ducts in liver, and in blood serum (at protein level) (PubMed:15072822). Detected in prostate and uterus (PubMed:9344668). Detected on basophils, but not neutrophils (PubMed:11342463). {ECO:0000269|PubMed:11342463, ECO:0000269|PubMed:15072822, ECO:0000269|PubMed:9344668}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6C01  (X-ray  2.30A  )  6C02  (X-ray  1.94A  ) 
DBSNP rs9321309  rs36094194  rs17601580 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:11342463};
Single-pass type II membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:15072822};
Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:15072822}. Note=Detected at the cell surface of basophils (PubMed:11342463). Detected at the apical plasma membrane of bile duct cells (PubMed:15072822). Located to the apical surface in intestinal and kidney epithelial cells. Secreted in serum, and in lumen of epithelial cells. {ECO:0000269|PubMed:11342463, ECO:0000269|PubMed:15072822}.
Mouse PG classificationNA
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