| Gene Information | |
|---|---|
| Gene Name | MED28 |
| Organism | Homo sapiens (Human) |
| Gene Length | 178 |
| Protein Names | Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000118579 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9H204 |
| Gene Card | MED28 |
| Uniprot ID | Q9H204 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.189865481) |
| Ortholog in Animals | Alpaca_ MED28 ( ortholog_one2one ) Dog_ MED28 ( ortholog_one2one ) GuineaPig_ MED28 ( ortholog_one2one ) Macaque_ MED28 ( ortholog_one2one ) Mouse_ Med28 ( ortholog_one2one ) Pig_ MED28 ( ortholog_one2one ) Rat_ Med28 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver. {ECO:0000269|PubMed:15467741}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001860(Rat);0.07021(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7EMF (EM 3.50A ) 7ENA (EM 4.07A ) 7ENC (EM 4.13A ) 7ENJ (EM 4.40A ) 7LBM (EM 4.80A ) 7NVR (EM 4.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15467741}. Cytoplasm {ECO:0000269|PubMed:15467741}. Membrane {ECO:0000269|PubMed:15467741}; Peripheral membrane protein {ECO:0000269|PubMed:15467741}. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated. |
| Mouse PG classification | NA |
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