| Gene Information | |
|---|---|
| Gene Name | MED25 |
| Organism | Homo sapiens (Human) |
| Gene Length | 747 |
| Protein Names | Mediator of RNA polymerase II transcription subunit 25 (Activator interaction domain-containing protein 1) (Activator-recruited cofactor 92 kDa component) (ARC92) (Mediator complex subunit 25) (p78) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000104973 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q71SY5 |
| Gene Card | MED25 |
| Uniprot ID | Q71SY5 |
| Pfam | PF11232; PF11244; PF11235; PF11265 |
| In ASD | yes |
| Allosteric Prediction | no (-0.479472253) |
| Ortholog in Animals | Alpaca_ MED25 ( ortholog_one2one ) Dog_ MED25 ( ortholog_one2one ) GuineaPig_ MED25 ( ortholog_one2one ) Macaque_ MED25 ( ortholog_one2one ) Mouse_ Med25 ( ortholog_one2one ) Pig_ MED25 ( ortholog_one2one ) Rat_ Med25 ( ortholog_one2one ) Rabbit_ MED25 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PTOV1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Highest levels in brain, heart, kidney, peripheral leukocytes, placenta, skeletal muscle and spleen. {ECO:0000269|PubMed:14657022, ECO:0000269|PubMed:14983011}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.024(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2KY6 (NMR - ) 2L23 (NMR - ) 2L6U (NMR - ) 2XNF (NMR - ) 7EMF (EM 3.50A ) 7LBM (EM 4.80A ) |
| DBSNP | rs794729668 rs781140315 rs145770066 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:14657022}. |
| Mouse PG classification | LPG |
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