| Gene Information | |
|---|---|
| Gene Name | TMEM150B |
| Organism | Homo sapiens (Human) |
| Gene Length | 233 |
| Protein Names | Modulator of macroautophagy TMEM150B (Protein DRAM-3) (Transmembrane protein 150B) (Transmembrane protein 224) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000180061 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | A6NC51 |
| Gene Card | TMEM150B |
| Uniprot ID | A6NC51 |
| Pfam | PF10277 |
| In ASD | no |
| Allosteric Prediction | no (-1.218575755) |
| Ortholog in Animals | Alpaca_ TMEM150B ( ortholog_one2one ) Dog_ TMEM150B ( ortholog_one2one ) GuineaPig_ TMEM150B ( ortholog_one2one ) Macaque_ TMEM150B ( ortholog_one2one ) Mouse_ Tmem150b ( ortholog_one2one ) Pig_ TMEM150B ( ortholog_one2one ) Rat_ Tmem150b ( ortholog_one2one ) Rabbit_ TMEM150B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TMEM150A, TMEM150C, DRAM1, DRAM2 |
| Tissue | duodenum, small.intestine |
| Tissue Specificity | Highly expressed in the colon and lung with comparatively high levels also detectable in the lymph nodes, placenta, duodenum, peripheral blood mononuclear cells and spleen (PubMed:25929859). {ECO:0000269|PubMed:25929859}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7246479 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:25608530, ECO:0000269|PubMed:25929859}; Multi-pass membrane protein {ECO:0000269|PubMed:25608530}. Endosome membrane {ECO:0000269|PubMed:25929859}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:25929859}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes mainly at the plasma membrane where it concentrates at actin-rich focal adhesions (PubMed:25608530, PubMed:25929859). {ECO:0000269|PubMed:25608530, ECO:0000269|PubMed:25929859}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |