| Gene Information | |
|---|---|
| Gene Name | SAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 524 |
| Protein Names | Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P07602 |
| Gene Card | PSAP |
| Uniprot ID | P07602 |
| Pfam | PF02199; PF05184; PF03489 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1M12 (NMR - ) 1N69 (X-ray 2.20A ) 1SN6 (NMR - ) 2DOB (X-ray 2.00A ) 2GTG (X-ray 2.40A ) 2QYP (X-ray 2.45A ) 2R0R (X-ray 2.50A ) 2R1Q (X-ray 2.50A ) 2RB3 (X-ray 2.10A ) 2Z9A (X-ray 2.50A ) 3BQP (X-ray 1.30A ) 3BQQ (X-ray 2.00A ) 4DDJ (X-ray 1.90A ) 4UEX (X-ray 1.80A ) 4V2O (X-ray 2.13A ) 6SLR (X-ray 2.38A ) |
| DBSNP | rs121918107 rs770171865 rs121918103 rs121918104 rs121918110 |
| Subcellular location [CC] | Lysosome {ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:21835174, ECO:0000269|PubMed:22431521}.; [Prosaposin]: Secreted {ECO:0000250|UniProtKB:Q61207}. Note=Secreted as a fully glycosylated 70 kDa protein composed of complex glycans. {ECO:0000250|UniProtKB:Q61207}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |