Gene Information
Gene NameSLC6A3
OrganismHomo sapiens (Human)
Gene Length620
Protein NamesSodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3)
Target Namedopamine transporter
Target TypeSuccessful target
Gene Age544 ( ENSG00000142319 )
3 ( ENSG00000276996 )
Evolutionary StageEumetazoa
AlphaFoldDBQ01959
Gene CardSLC6A3
Uniprot IDQ01959
PfamPF00209
In ASDyes
Allosteric Predictionyes (1.540282122)
Ortholog in AnimalsAlpaca_ SLC6A3 ( ortholog_one2one )
Dog_ SLC6A3 ( ortholog_one2one )
GuineaPig_ SLC6A3 ( ortholog_one2one )
Macaque_ SLC6A3 ( ortholog_one2one )
Mouse_ Slc6a3 ( ortholog_one2one )
Pig_ SLC6A3 ( ortholog_one2one )
Rat_ Slc6a3 ( ortholog_one2one )
OhnologsSLC6A2
ParalogsSLC6A20, SLC6A9, SLC6A2, SLC6A18, SLC6A7, SLC6A4, SLC6A16, SLC6A8, SLC6A5, SLC6A14, SLC6A6, SLC6A15, SLC6A13, SLC6A11, SLC6A19, SLC6A1, SLC6A17, SLC6A12
Tissuesubstantia.nigra
Tissue SpecificityHighly expressed in substantia nigra (PubMed:7637582). Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level) (PubMed:17296554). Expressed in the striatum (at protein level) (PubMed:17296554). {ECO:0000269|PubMed:17296554, ECO:0000269|PubMed:7637582}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs760871529  rs6345  rs267607068  rs267607069  rs75916702 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:11343649, ECO:0000269|PubMed:15505207};
Multi-pass membrane protein {ECO:0000255}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P23977}. Cell projection, axon {ECO:0000269|PubMed:17296554}. Note=Localizes to neurite tips in neuronal cells (By similarity). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity). {ECO:0000250|UniProtKB:P23977, ECO:0000250|UniProtKB:Q61327}.
Mouse PG classificationNA
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