Gene Information
Gene NameKMT5A
OrganismHomo sapiens (Human)
Gene Length393
Protein NamesN-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.361) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8)
Target NameNA
Target TypeNA
Gene Age332 ( ENSG00000183955 )
Evolutionary StageEukaryota
AlphaFoldDBQ9NQR1
Gene CardKMT5A
Uniprot IDQ9NQR1
PfamPF00856
In ASDyes
Allosteric Predictionyes (0.036364756)
Ortholog in AnimalsAlpaca_ KMT5A ( ortholog_one2one )
Alpaca_ KMT5A ( ortholog_one2many )
GuineaPig_ KMT5A ( ortholog_one2one )
Macaque_ KMT5A ( ortholog_one2one )
Mouse_ Kmt5a ( ortholog_one2one )
Pig_ KMT5A ( ortholog_one2one )
Rat_ AABR07010705.1 ( ortholog_one2many )
Rat_ AABR07033047.1 ( ortholog_one2many )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002101(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1ZKK  (X-ray  1.45A  )  2BQZ  (X-ray  1.50A  )  3F9W  (X-ray  1.60A  )  3F9X  (X-ray  1.25A  )  3F9Y  (X-ray  1.50A  )  3F9Z  (X-ray  1.60A  )  4IJ8  (X-ray  2.00A  )  5HQ2  (X-ray  4.50A  )  5T5G  (X-ray  2.10A  )  5TEG  (X-ray  1.30A  )  5TH7  (X-ray  1.95A  )  5V2N  (X-ray  2.00A  )  5W1Y  (X-ray  1.70A  )  6BOZ  (X-ray  2.40A  )  7D1Z  (EM  3.15A  )  7D20  (EM  3.00A  )  7XPX  (EM  3.20A  ) 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:12086618}. Chromosome {ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:12208845, ECO:0000269|PubMed:23468428}. Note=Specifically localizes to mitotic chromosomes (PubMed:12208845). Colocalized with SIRT2 at mitotic foci (PubMed:23468428). Associates with chromosomes during mitosis;
association is increased in a H(2)O(2)-induced oxidative stress-dependent manner (PubMed:23468428). Associates with silent chromatin on euchromatic arms (PubMed:12086618). Not associated with constitutive heterochromatin (PubMed:12086618). {ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:12208845, ECO:0000269|PubMed:23468428}.
Mouse PG classificationNA
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