| Gene Information | |
|---|---|
| Gene Name | ME2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 584 |
| Protein Names | NAD-dependent malic enzyme, mitochondrial (NAD-ME) (EC 1.1.1.38) (Malic enzyme 2) |
| Target Name | nad-dependent malic enzyme, mitochondrial |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000082212 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P23368 |
| Gene Card | ME2 |
| Uniprot ID | P23368 |
| Pfam | PF00390; PF03949 |
| In ASD | yes |
| Allosteric Prediction | yes (1.00015976) |
| Ortholog in Animals | Alpaca_ ME2 ( ortholog_one2one ) Dog_ ME2 ( ortholog_one2one ) GuineaPig_ ME2 ( ortholog_one2one ) Macaque_ ME2 ( ortholog_one2one ) Mouse_ Me2 ( ortholog_one2one ) Pig_ ME2 ( ortholog_one2one ) Rat_ Me2 ( ortholog_one2one ) Rabbit_ ME2 ( ortholog_one2one ) |
| Ohnologs | ME1, ME3 |
| Paralogs | ME1, ME3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DO8 (X-ray 2.20A ) 1EFK (X-ray 2.60A ) 1EFL (X-ray 2.60A ) 1GZ3 (X-ray 2.30A ) 1GZ4 (X-ray 2.20A ) 1PJ2 (X-ray 2.30A ) 1PJ3 (X-ray 2.10A ) 1PJ4 (X-ray 2.30A ) 1PJL (X-ray 2.90A ) 1QR6 (X-ray 2.10A ) 7BSJ (X-ray 2.48A ) 7BSK (X-ray 2.55A ) 7BSL (X-ray 2.55A ) |
| DBSNP | rs16952692 rs649224 |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000269|PubMed:1993674}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |