| Gene Information | |
|---|---|
| Gene Name | GPBAR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 330 |
| Protein Names | G-protein coupled bile acid receptor 1 (G-protein coupled receptor GPCR19) (hGPCR19) (Membrane-type receptor for bile acids) (M-BAR) (hBG37) (BG37) |
| Target Name | g-protein coupled bile acid receptor 1 |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000179921 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8TDU6 |
| Gene Card | GPBAR1 |
| Uniprot ID | Q8TDU6 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.196517581) |
| Ortholog in Animals | Alpaca_ GPBAR1 ( ortholog_one2one ) Dog_ GPBAR1 ( ortholog_one2one ) GuineaPig_ GPBAR1 ( ortholog_one2one ) Macaque_ GPBAR1 ( ortholog_one2one ) Mouse_ Gpbar1 ( ortholog_one2one ) Pig_ GPBAR1 ( ortholog_one2one ) Rat_ Gpbar1 ( ortholog_one2one ) Rabbit_ GPBAR1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | adipose.tissue, gall.bladder |
| Tissue Specificity | Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum. {ECO:0000269|PubMed:12044878, ECO:0000269|PubMed:12419312, ECO:0000269|PubMed:12524422}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7BW0 (EM 3.90A ) 7CFM (EM 3.00A ) 7CFN (EM 3.00A ) 7XTQ (EM 3.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12524422}; Multi-pass membrane protein {ECO:0000269|PubMed:12524422}. |
| Mouse PG classification | NA |
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