| Gene Information | |
|---|---|
| Gene Name | HERPUD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 391 |
| Protein Names | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000051108 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15011 |
| Gene Card | HERPUD1 |
| Uniprot ID | Q15011 |
| Pfam | PF00240 |
| In ASD | no |
| Allosteric Prediction | yes (0.041499983) |
| Ortholog in Animals | Alpaca_ HERPUD1 ( ortholog_one2one ) Dog_ HERPUD1 ( ortholog_one2one ) GuineaPig_ HERPUD1 ( ortholog_one2one ) Macaque_ HERPUD1 ( ortholog_one2one ) Mouse_ Herpud1 ( ortholog_one2one ) Pig_ HERPUD1 ( ortholog_one2one ) Rat_ Herpud1 ( ortholog_one2one ) Rabbit_ HERPUD1 ( ortholog_one2one ) |
| Ohnologs | HERPUD2 |
| Paralogs | HERPUD2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1WGD (NMR - ) |
| DBSNP | rs2217332 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10922362}; Multi-pass membrane protein {ECO:0000269|PubMed:10922362}. |
| Mouse PG classification | NA |
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