| Gene Information | |
|---|---|
| Gene Name | MDR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1286 |
| Protein Names | Phosphatidylcholine translocator ABCB4 (EC 7.6.2.1) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (P-glycoprotein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P21439 |
| Gene Card | ABCB4 |
| Uniprot ID | P21439 |
| Pfam | PF00664; PF00005 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6S7P (EM 3.20A ) 7NIU (EM 4.20A ) 7NIV (EM 3.60A ) 7NIW (EM 3.80A ) |
| DBSNP | rs142794414 rs372685632 rs1343667900 rs780641693 rs8187788 rs1411970557 rs377268767 rs1408217402 rs1021988376 rs72552781 rs757693457 rs58238559 rs753318087 rs45596335 rs45547936 rs765478923 rs72552779 rs72552778 rs67876345 rs1168923653 rs72552777 rs121918443 rs763807769 rs1263565476 rs1189003716 rs748657435 rs375315619 rs1257887155 rs8187797 rs66904256 rs121918441 rs761238221 rs1562975478 rs45575636 rs72552776 rs571555115 rs372476723 rs972726699 rs45476795 rs2230028 rs988987669 rs72552773 rs138773456 rs141677867 rs970324585 rs147134978 rs148052192 rs8187801 rs61730509 rs779829759 rs759787957 rs1051861187 rs56187107 rs1214110864 rs1262922848 rs121918442 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23468132, ECO:0000269|PubMed:24045840, ECO:0000269|PubMed:24806754, ECO:0000269|PubMed:28012258}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Apical cell membrane {ECO:0000269|PubMed:15258199, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:21820390, ECO:0000269|PubMed:24122873, ECO:0000269|PubMed:24594635, ECO:0000269|PubMed:24723470, ECO:0000269|PubMed:8898203}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Membrane raft {ECO:0000269|PubMed:23468132}. Cytoplasm {ECO:0000269|PubMed:24045840}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q08201}. Note=Localized at the apical canalicular membrane of the epithelial cells lining the lumen of the bile canaliculi and biliary ductules (By similarity). Transported from the Golgi to the apical bile canalicular membrane in a RACK1-dependent manner (PubMed:19674157). Redistributed into pseudocanaliculi formed between cells in a bezafibrate- or PPARA-dependent manner (PubMed:15258199). Localized preferentially in lipid nonraft domains of canalicular plasma membranes (PubMed:23468132). {ECO:0000250|UniProtKB:P21440, ECO:0000269|PubMed:15258199, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:23468132}. |
| Mouse PG classification | NA |
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