| Gene Information | |
|---|---|
| Gene Name | TMCO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 239 |
| Protein Names | Calcium load-activated calcium channel (CLAC channel) (Transmembrane and coiled-coil domain-containing protein 1) (Transmembrane and coiled-coil domains protein 4) (Xenogeneic cross-immune protein PCIA3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000143183 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UM00 |
| Gene Card | TMCO1 |
| Uniprot ID | Q9UM00 |
| Pfam | PF01956 |
| In ASD | no |
| Allosteric Prediction | no (-0.499695724) |
| Ortholog in Animals | Alpaca_ TMCO1 ( ortholog_one2one ) Dog_ TMCO1 ( ortholog_one2one ) GuineaPig_ TMCO1 ( ortholog_one2one ) Macaque_ TMCO1 ( ortholog_one2one ) Mouse_ Tmco1 ( ortholog_one2one ) Pig_ TMCO1 ( ortholog_one2one ) Rat_ Tmco1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed in adult and fetal tissues, with higher levels in thymus, prostate, testis and small intestine and lower levels in brain, placenta, lung and kidney (PubMed:10393320, PubMed:20018682). Present in most tissues in the eye, including the trabecular meshwork and retina (at protein level) (PubMed:22714896). {ECO:0000269|PubMed:10393320, ECO:0000269|PubMed:20018682, ECO:0000269|PubMed:22714896}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6W6L (EM 3.84A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10393320, ECO:0000269|PubMed:27212239}; Multi-pass membrane protein {ECO:0000269|PubMed:10393320, ECO:0000269|PubMed:27212239}. Golgi apparatus membrane {ECO:0000269|PubMed:10393320}; Multi-pass membrane protein {ECO:0000269|PubMed:10393320}. Note=The first transmembrane region is required for localization to the endoplasmic reticulum (PubMed:27212239). A publication reported localization in cytoplasm and nucleus (PubMed:22714896). Nuclear localization is however in contradiction with two other reports (PubMed:10393320, PubMed:27212239). {ECO:0000269|PubMed:10393320, ECO:0000269|PubMed:22714896, ECO:0000269|PubMed:27212239}. |
| Mouse PG classification | NA |
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