| Gene Information | |
|---|---|
| Gene Name | MDM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 491 |
| Protein Names | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) |
| Target Name | mdm2 messenger rna |
| Target Type | Literature-reported target |
| Gene Age | 950 ( ENSG00000135679 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q00987 |
| Gene Card | MDM2 |
| Uniprot ID | Q00987 |
| Pfam | PF02201; PF00641 |
| In ASD | yes |
| Allosteric Prediction | yes (1.527713716) |
| Ortholog in Animals | Alpaca_ MDM2 ( ortholog_one2one ) Dog_ MDM2 ( ortholog_one2one ) GuineaPig_ MDM2 ( ortholog_one2one ) Macaque_ MDM2 ( ortholog_one2one ) Mouse_ Mdm2 ( ortholog_one2one ) Pig_ MDM2 ( ortholog_one2one ) Rat_ Mdm2 ( ortholog_one2one ) |
| Ohnologs | MDM4 |
| Paralogs | MDM4 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.082431(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1RV1 (X-ray 2.30A ) 1T4E (X-ray 2.60A ) 1T4F (X-ray 1.90A ) 1YCR (X-ray 2.60A ) 1Z1M (NMR - ) 2AXI (X-ray 1.40A ) 2C6A (NMR - ) 2C6B (NMR - ) 2F1Y (X-ray 1.70A ) 2FOP (X-ray 2.10A ) 2GV2 (X-ray 1.80A ) 2HDP (NMR - ) 2LZG (NMR - ) 2M86 (NMR - ) 2MPS (NMR - ) 2RUH (NMR - ) 2VJE (X-ray 2.20A ) 2VJF (X-ray 2.30A ) 3EQS (X-ray 1.65A ) 3G03 (X-ray 1.80A ) 3IUX (X-ray 1.65A ) 3IWY (X-ray 1.93A ) 3JZK (X-ray 2.10A ) 3JZR (X-ray 2.10A ) 3JZS (X-ray 1.78A ) 3LBK (X-ray 2.30A ) 3LBL (X-ray 1.60A ) 3LNJ (X-ray 2.40A ) 3LNZ (X-ray 1.95A ) 3MQS (X-ray 2.40A ) 3TJ2 (X-ray 2.10A ) 3TPX (X-ray 1.80A ) 3TU1 (X-ray 1.60A ) 3V3B (X-ray 2.00A ) 3VBG (X-ray 2.80A ) 3VZV (X-ray 2.80A ) 3W69 (X-ray 1.90A ) 4DIJ (X-ray 1.90A ) 4ERE (X-ray 1.80A ) 4ERF (X-ray 2.00A ) 4HBM (X-ray 1.90A ) 4HFZ (X-ray 2.69A ) 4HG7 (X-ray 1.60A ) 4JV7 (X-ray 2.20A ) 4JV9 (X-ray 2.50A ) 4JVE (X-ray 2.30A ) 4JVR (X-ray 1.70A ) 4JWR (X-ray 2.35A ) 4MDN (X-ray 1.90A ) 4MDQ (X-ray 2.12A ) 4OAS (X-ray 1.70A ) 4OBA (X-ray 1.60A ) 4OCC (X-ray 1.80A ) 4ODE (X-ray 1.80A ) 4ODF (X-ray 2.20A ) 4OGN (X-ray 1.38A ) 4OGT (X-ray 1.54A ) 4OGV (X-ray 2.20A ) 4OQ3 (X-ray 2.30A ) 4QO4 (X-ray 1.70A ) 4QOC (X-ray 1.70A ) 4UD7 (X-ray 1.60A ) 4UE1 (X-ray 1.45A ) 4UMN (X-ray 1.99A ) 4WT2 (X-ray 1.42A ) 4XXB (X-ray 2.40A ) 4ZFI (X-ray 2.00A ) 4ZGK (X-ray 2.00A ) 4ZYC (X-ray 1.95A ) 4ZYF (X-ray 1.80A ) 4ZYI (X-ray 1.67A ) 5AFG (X-ray 1.90A ) 5C5A (X-ray 1.15A ) 5HMH (X-ray 1.79A ) 5HMI (X-ray 1.74A ) 5HMK (X-ray 2.17A ) 5J7F (X-ray 2.00A ) 5J7G (X-ray 1.85A ) 5LAV (X-ray 1.73A ) 5LAW (X-ray 1.64A ) 5LAY (X-ray 2.71A ) 5LAZ (X-ray 1.66A ) 5LN2 (X-ray 1.58A ) 5MNJ (X-ray 2.16A ) 5OAI (X-ray 2.00A ) 5OC8 (X-ray 1.56A ) 5SWK (X-ray 1.92A ) 5TRF (X-ray 2.10A ) 5UMM (X-ray 1.65A ) 5VK0 (X-ray 1.80A ) 5WTS (X-ray 3.00A ) 5XXK (X-ray 1.66A ) 5Z02 (X-ray 1.35A ) 5ZXF (X-ray 1.25A ) 6AAW (X-ray 2.00A ) 6GGN (X-ray 2.00A ) 6H22 (X-ray 2.01A ) 6HFA (X-ray 1.79A ) 6I29 (X-ray 2.10A ) 6I3S (X-ray 1.77A ) 6IM9 (X-ray 3.30A ) 6KZU (X-ray 1.79A ) 6Q96 (X-ray 1.80A ) 6Q9H (X-ray 2.00A ) 6Q9L (X-ray 1.13A ) 6Q9O (X-ray 1.21A ) 6SQO (X-ray 1.41A ) 6T2D (X-ray 1.80A ) 6T2E (X-ray 2.40A ) 6T2F (X-ray 2.09A ) 6Y4Q (X-ray 1.63A ) 6YR6 (X-ray 1.75A ) 7AD0 (X-ray 2.07A ) 7AI0 (X-ray 1.56A ) 7AI1 (X-ray 2.07A ) 7AYE (X-ray 2.95A ) 7BIR (X-ray 2.02A ) 7BIT (X-ray 2.13A ) 7BIV (X-ray 1.64A ) 7BJ0 (X-ray 2.00A ) 7BJ6 (X-ray 1.59A ) 7BMG (X-ray 1.83A ) 7KJM (X-ray 1.40A ) 7NA1 (X-ray 2.30A ) 7NA2 (X-ray 1.86A ) 7NA3 (X-ray 2.21A ) 7NA4 (X-ray 1.84A ) 7NUS (X-ray 1.45A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus, nucleoplasm. Cytoplasm {ECO:0000269|PubMed:30879903}. Nucleus, nucleolus. Nucleus {ECO:0000269|PubMed:30879903}. Note=Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus. |
| Mouse PG classification | NA |
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