| Gene Information | |
|---|---|
| Gene Name | CLEC4E |
| Organism | Homo sapiens (Human) |
| Gene Length | 219 |
| Protein Names | C-type lectin domain family 4 member E (C-type lectin superfamily member 9) (Macrophage-inducible C-type lectin) (MINCLE) |
| Target Name | c-type lectin domain family 4 member e |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000166523 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9ULY5 |
| Gene Card | CLEC4E |
| Uniprot ID | Q9ULY5 |
| Pfam | PF00059 |
| In ASD | no |
| Allosteric Prediction | no (-0.550882158) |
| Ortholog in Animals | Alpaca_ CLEC4E ( ortholog_one2one ) Dog_ CLEC4E ( ortholog_one2one ) GuineaPig_ CLEC4E ( ortholog_one2one ) Macaque_ CLEC4E ( ortholog_one2one ) Mouse_ Clec4e ( ortholog_one2one ) Rat_ Clec4e ( ortholog_one2one ) Rabbit_ CLEC4E ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ASGR1, CLEC4G, CLEC4C, CLEC4M, CLEC17A, ASGR2, CLEC4A, CLEC4F, CLEC10A, CLEC6A, FCER2, CD209, CLEC4D, CD207 |
| Tissue | appendix, spleen, adipose.tissue, brain, lung, whole.blood |
| Tissue Specificity | Expressed in monocytes and macrophages. {ECO:0000269|PubMed:23602766}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3WH2 (X-ray 1.30A ) 3WH3 (X-ray 1.32A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18490740, ECO:0000305|PubMed:24101491}; Single-pass type II membrane protein {ECO:0000305}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q9R0Q8}. |
| Mouse PG classification | NA |
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