| Gene Information | |
|---|---|
| Gene Name | MDCR |
| Organism | Homo sapiens (Human) |
| Gene Length | 410 |
| Protein Names | Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P43034 |
| Gene Card | PAFAH1B1 |
| Uniprot ID | P43034 |
| Pfam | PF08513; PF00400 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Fairly ubiquitous expression in both the frontal and occipital areas of the brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001942(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7MT1 (X-ray 1.30A ) |
| DBSNP | rs121434486 rs121434482 rs121434487 rs121434484 rs121434488 rs121434490 rs121434485 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, spindle {ECO:0000255|HAMAP-Rule:MF_03141}. Nucleus membrane {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes (By similarity). Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. {ECO:0000250}. |
| Mouse PG classification | NA |
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