| Gene Information | |
|---|---|
| Gene Name | MAP2K2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 400 |
| Protein Names | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) |
| Target Name | erk activator kinase 2 |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000126934 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P36507 |
| Gene Card | MAP2K2 |
| Uniprot ID | P36507 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000264626) |
| Ortholog in Animals | Alpaca_ MAP2K2 ( ortholog_one2one ) Dog_ MAP2K2 ( ortholog_one2one ) GuineaPig_ MAP2K2 ( ortholog_one2one ) Macaque_ MAP2K2 ( ortholog_one2one ) Mouse_ Map2k2 ( ortholog_one2one ) Pig_ MAP2K2 ( ortholog_one2one ) Rat_ Map2k2 ( ortholog_one2one ) |
| Ohnologs | MAP2K1 |
| Paralogs | NEK1, MAP3K2, MAP3K4, MAP2K4, MAP3K3, MAP2K7, MAP2K5, MAP2K1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1S9I (X-ray 3.20A ) 4H3Q (X-ray 2.20A ) |
| DBSNP | rs121434497 rs121434498 rs267607230 rs121434499 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10409742}. Membrane {ECO:0000269|PubMed:10409742}; Peripheral membrane protein {ECO:0000269|PubMed:10409742}. Note=Membrane localization is probably regulated by its interaction with KSR1. {ECO:0000269|PubMed:10409742}. |
| Mouse PG classification | LPG |
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