| Gene Information | |
|---|---|
| Gene Name | MCU |
| Organism | Homo sapiens (Human) |
| Gene Length | 351 |
| Protein Names | Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000156026 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8NE86 |
| Gene Card | MCU |
| Uniprot ID | Q8NE86 |
| Pfam | PF04678 |
| In ASD | no |
| Allosteric Prediction | no (-0.352614918) |
| Ortholog in Animals | Alpaca_ MCU ( ortholog_one2one ) Dog_ MCU ( ortholog_one2one ) GuineaPig_ MCU ( ortholog_one2one ) Macaque_ MCU ( ortholog_one2one ) Mouse_ Mcu ( ortholog_one2one ) Pig_ MCU ( ortholog_one2one ) Rat_ Mcu ( ortholog_one2one ) Rabbit_ MCU ( ortholog_one2one ) |
| Ohnologs | MCUB |
| Paralogs | MCUB |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.186667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4XSJ (X-ray 1.80A ) 4XTB (X-ray 1.50A ) 5BZ6 (X-ray 2.75A ) 5KUE (X-ray 1.50A ) 5KUG (X-ray 1.90A ) 5KUI (X-ray 2.70A ) 5KUJ (X-ray 1.60A ) 6JG0 (X-ray 2.50A ) 6K7X (EM 3.27A ) 6K7Y (EM 3.60A ) 6KVX (X-ray 2.85A ) 6O58 (EM 3.80A ) 6O5B (EM 3.60A ) 6WDN (EM 3.20A ) 6WDO (EM 3.60A ) 6XJV (EM 4.17A ) 6XJX (EM 4.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:23755363, ECO:0000269|PubMed:24231807, ECO:0000269|PubMed:27099988, ECO:0000305|PubMed:26341627}; Multi-pass membrane protein {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:24231807}. |
| Mouse PG classification | NA |
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