| Gene Information | |
|---|---|
| Gene Name | HELLS |
| Organism | Homo sapiens (Human) |
| Gene Length | 838 |
| Protein Names | Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000119969 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NRZ9 |
| Gene Card | HELLS |
| Uniprot ID | Q9NRZ9 |
| Pfam | PF00271; PF00176 |
| In ASD | no |
| Allosteric Prediction | no (-0.389426663) |
| Ortholog in Animals | Alpaca_ HELLS ( ortholog_one2one ) Dog_ HELLS ( ortholog_one2one ) GuineaPig_ HELLS ( ortholog_one2one ) Macaque_ HELLS ( ortholog_one2one ) Mouse_ Hells ( ortholog_one2one ) Pig_ HELLS ( ortholog_one2one ) Rat_ Hells ( ortholog_one2one ) Rabbit_ HELLS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SMARCA1, RAD54B, HLTF, SHPRH, BTAF1, ZRANB3, SMARCA5, TTF2, SMARCA2, CHD9, SMARCAL1, CHD1L, CHD3, RAD54L2, SMARCAD1, CHD4, ATRX, INO80, CHD6, SRCAP, CHD1, CHD2, RAD54L, CHD7, CHD8, EP400, ERCC6, ERCC6L, CHD5, SMARCA4 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias. {ECO:0000269|PubMed:10910076}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs879253733 |
| Subcellular location [CC] | Nucleus {ECO:0000250}. Note=Closely associated with pericentric heterochromatin. {ECO:0000250}. |
| Mouse PG classification | LPG |
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