| Gene Information | |
|---|---|
| Gene Name | MCT8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 539 |
| Protein Names | Monocarboxylate transporter 8 (MCT 8) (Monocarboxylate transporter 7) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P36021 |
| Gene Card | SLC16A2 |
| Uniprot ID | P36021 |
| Pfam | PF07690 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in liver and heart (PubMed:7981683). In adult brain tissue expression is largely confined to endothelial cells of the blood-brain barrier (at protein level) (PubMed:32143555, PubMed:18687783). {ECO:0000269|PubMed:18687783, ECO:0000269|PubMed:32143555, ECO:0000269|PubMed:7981683}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs113994162 rs1602140936 rs373279555 rs104894936 rs727504155 rs398124232 rs12849411 rs104894939 rs587784384 rs122455132 rs113994164 rs104894931 rs794727799 rs104894938 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20628049, ECO:0000269|PubMed:23550058, ECO:0000269|PubMed:25527620, ECO:0000269|PubMed:26426690}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:18687783}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |