| Gene Information | |
|---|---|
| Gene Name | INHA |
| Organism | Homo sapiens (Human) |
| Gene Length | 366 |
| Protein Names | Inhibin alpha chain |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000123999 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P05111 |
| Gene Card | INHA |
| Uniprot ID | P05111 |
| Pfam | PF00019 |
| In ASD | no |
| Allosteric Prediction | no (-0.328967412) |
| Ortholog in Animals | Alpaca_ INHA ( ortholog_one2one ) Dog_ INHA ( ortholog_one2one ) GuineaPig_ INHA ( ortholog_one2one ) Macaque_ INHA ( ortholog_one2one ) Mouse_ Inha ( ortholog_one2one ) Pig_ INHA ( ortholog_one2one ) Rat_ Inha ( ortholog_one2one ) Rabbit_ INHA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BMP3, MSTN, INHBC, GDF15, BMP6, INHBA, GDF6, TGFB3, BMP2, BMP10, TGFB1, GDF9, GDF11, BMP5, BMP7, INHBB, GDF5, GDF1, GDF2, BMP4, LEFTY1, LEFTY2, GDF3, INHBE, GDF7, GDF10, BMP15, TGFB2, BMP8A, BMP8B, NODAL |
| Tissue | testis, adrenal.gland, ovary |
| Tissue Specificity | Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female. {ECO:0000269|PubMed:9506758}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12720061 rs12720062 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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