Gene Information
Gene NameFLOT1
OrganismHomo sapiens (Human)
Gene Length591
Protein NamesReduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1)
Target NameNA
Target TypeNA
Gene Age950 ( ENSG00000137312 )
3 ( ENSG00000206379 )
3 ( ENSG00000206480 )
3 ( ENSG00000223654 )
3 ( ENSG00000224740 )
3 ( ENSG00000230143 )
3 ( ENSG00000232280 )
3 ( ENSG00000236271 )
Evolutionary StageEuk+Bac
AlphaFoldDBP41440
Gene CardSLC19A1
Uniprot IDP41440
PfamPF01770
In ASDno
Allosteric Predictionno (-0.199688166)
Ortholog in AnimalsAlpaca_ FLOT1 ( ortholog_one2one )
Dog_ FLOT1 ( ortholog_one2one )
GuineaPig_ FLOT1 ( ortholog_one2one )
Macaque_ FLOT1 ( ortholog_one2one )
Mouse_ Flot1 ( ortholog_one2one )
Pig_ FLOT1 ( ortholog_one2one )
Rat_ Flot1 ( ortholog_one2one )
Rabbit_ FLOT1 ( ortholog_one2one )
OhnologsNA
ParalogsFLOT2
TissueNA
Tissue SpecificityPlacenta, liver, and to a much smaller extent, in lung. {ECO:0000269|PubMed:7826387}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs1051266  rs757838708  rs35786590 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:10347183, ECO:0000269|PubMed:10787414, ECO:0000269|PubMed:15337749, ECO:0000269|PubMed:16115875, ECO:0000269|PubMed:9767079};
Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:10787414};
Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:10787414};
Multi-pass membrane protein {ECO:0000255}.
Mouse PG classificationNA
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