| Gene Information | |
|---|---|
| Gene Name | HAS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 552 |
| Protein Names | Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid synthase 2) (HA synthase 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000170961 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q92819 |
| Gene Card | HAS2 |
| Uniprot ID | Q92819 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.0810145) |
| Ortholog in Animals | Alpaca_ HAS2 ( ortholog_one2one ) Dog_ HAS2 ( ortholog_one2one ) GuineaPig_ HAS2 ( ortholog_one2one ) Macaque_ HAS2 ( ortholog_one2one ) Mouse_ Has2 ( ortholog_one2one ) Pig_ HAS2 ( ortholog_one2one ) Rat_ Has2 ( ortholog_one2one ) Rabbit_ HAS2 ( ortholog_one2one ) |
| Ohnologs | HAS3 |
| Paralogs | HAS3, HAS1 |
| Tissue | NA |
| Tissue Specificity | Expressed in fibroblasts. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:22887999, ECO:0000269|PubMed:25795779, ECO:0000269|PubMed:30394292, ECO:0000269|PubMed:8798477}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30394292}; Multi-pass membrane protein {ECO:0000255}. Vesicle {ECO:0000269|PubMed:30394292}. Golgi apparatus membrane {ECO:0000269|PubMed:25795779, ECO:0000269|PubMed:30394292}; Multi-pass membrane protein {ECO:0000255}. Lysosome {ECO:0000269|PubMed:30394292}. Note=Travels from endoplasmic reticulum (ER), Golgi to plasma membrane and either back to endosomes and lysosomes, or out into extracellular vesicles (PubMed:30394292). Post-translational modifications control HAS2 trafficking (PubMed:30394292). {ECO:0000269|PubMed:30394292}. |
| Mouse PG classification | NA |
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