| Gene Information | |
|---|---|
| Gene Name | MCPH1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 835 |
| Protein Names | Microcephalin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000147316 ) 3 ( ENSG00000285262 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8NEM0 |
| Gene Card | MCPH1 |
| Uniprot ID | Q8NEM0 |
| Pfam | PF16589; PF12258; PF12738 |
| In ASD | no |
| Allosteric Prediction | no (-0.51457717) |
| Ortholog in Animals | Alpaca_ MCPH1 ( ortholog_one2one ) Dog_ MCPH1 ( ortholog_one2one ) GuineaPig_ MCPH1 ( ortholog_one2one ) Macaque_ MCPH1 ( ortholog_one2one ) Mouse_ Mcph1 ( ortholog_one2one ) Pig_ MCPH1 ( ortholog_one2one ) Rat_ Mcph1 ( ortholog_one2one ) Rabbit_ MCPH1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in fetal brain, liver and kidney. {ECO:0000269|PubMed:12046007}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001704(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2WT8 (X-ray 1.60A ) 3KTF (X-ray 1.60A ) 3PA6 (X-ray 1.50A ) 3SHT (X-ray 1.95A ) 3SHV (X-ray 2.10A ) 3SZM (X-ray 2.63A ) 3T1N (X-ray 2.60A ) 3U3Z (X-ray 1.50A ) 7C5D (X-ray 2.15A ) |
| DBSNP | rs199422124 rs2442513 rs2922828 rs34121009 rs35590577 rs2083914 rs930557 rs2515569 rs17076894 rs34418490 rs12674488 rs1057090 rs1057091 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16479174}. |
| Mouse PG classification | NA |
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