| Gene Information | |
|---|---|
| Gene Name | AIMP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 312 |
| Protein Names | Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-2) (Endothelial monocyte-activating polypeptide II) (EMAP-II) (Small inducible cytokine subfamily E member 1)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000164022 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q12904 |
| Gene Card | AIMP1 |
| Uniprot ID | Q12904 |
| Pfam | PF01588 |
| In ASD | no |
| Allosteric Prediction | no (-0.578060401) |
| Ortholog in Animals | Alpaca_ AIMP1 ( ortholog_one2one ) Dog_ AIMP1 ( ortholog_one2many ) GuineaPig_ AIMP1 ( ortholog_one2one ) Macaque_ AIMP1 ( ortholog_one2one ) Mouse_ Aimp1 ( ortholog_one2one ) Pig_ AIMP1 ( ortholog_one2one ) Rat_ Aimp1 ( ortholog_one2one ) Rabbit_ AIMP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1E7Z (X-ray 2.05A ) 1EUJ (X-ray 1.80A ) 1FL0 (X-ray 1.50A ) 4R3Z (X-ray 4.03A ) |
| DBSNP | rs1134648 rs113844295 rs2230255 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:14500886}. Cytoplasm, cytosol {ECO:0000269|PubMed:19289464}. Secreted {ECO:0000269|PubMed:10850427}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P31230}. Golgi apparatus {ECO:0000250|UniProtKB:P31230}. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Secreted in response to hypoxia (PubMed:10850427). Also secreted in response to both apoptotic and necrotic cell death. {ECO:0000250|UniProtKB:P31230, ECO:0000269|PubMed:10850427}. |
| Mouse PG classification | NA |
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