| Gene Information | |
|---|---|
| Gene Name | EXOC8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 725 |
| Protein Names | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000116903 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IYI6 |
| Gene Card | EXOC8 |
| Uniprot ID | Q8IYI6 |
| Pfam | PF16528 |
| In ASD | no |
| Allosteric Prediction | no (-1.023690652) |
| Ortholog in Animals | Alpaca_ EXOC8 ( ortholog_one2one ) Dog_ EXOC8 ( ortholog_one2one ) GuineaPig_ EXOC8 ( ortholog_one2one ) Macaque_ EXOC8 ( ortholog_one2one ) Mouse_ Exoc8 ( ortholog_one2one ) Pig_ EXOC8 ( ortholog_one2one ) Rat_ Exoc8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.006377(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs483352868 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:O54924}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54924}. Cell projection, growth cone {ECO:0000250|UniProtKB:O54924}. Cell projection {ECO:0000250|UniProtKB:O54924}. Note=Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during neuronal differentiation (By similarity). Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups (By similarity). Localizes at the leading edge of migrating cells (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O54924}. |
| Mouse PG classification | NA |
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