Gene Information
Gene NamePDGFRA
OrganismHomo sapiens (Human)
Gene Length1089
Protein NamesPlatelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Target Nameplatelet-derived growth factor receptor alpha
Target TypeSuccessful target
Gene Age645 ( ENSG00000134853 )
Evolutionary StageVertebrata
AlphaFoldDBP16234
Gene CardPDGFRA
Uniprot IDP16234
PfamPF07679; PF07714
In ASDyes
Allosteric Predictionyes (1.064320803)
Ortholog in AnimalsAlpaca_ PDGFRA ( ortholog_one2one )
Dog_ PDGFRA ( ortholog_one2one )
GuineaPig_ PDGFRA ( ortholog_one2one )
Macaque_ PDGFRA ( ortholog_one2one )
Mouse_ Pdgfra ( ortholog_one2one )
Pig_ PDGFRA ( ortholog_one2one )
Rat_ Pdgfra ( ortholog_one2one )
Rabbit_ PDGFRA ( ortholog_one2one )
OhnologsFLT4, FLT1, PDGFRB, FLT3, CSF1R
ParalogsEPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET
TissueNA
Tissue SpecificityDetected in platelets (at protein level). Widely expressed. Detected in brain, fibroblasts, smooth muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue. {ECO:0000269|PubMed:2536956, ECO:0000269|PubMed:7896447, ECO:0000269|PubMed:8188664}.
Pharmacological Animal Models0.032198(Chimpanzee);0.015233(Mouse);0.002657(Rat);0.030000(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1GQ5  (X-ray  2.20A  )  5GRN  (X-ray  1.77A  )  5K5X  (X-ray  2.17A  )  6A32  (X-ray  1.87A  )  6JOI  (X-ray  3.10A  )  6JOJ  (X-ray  2.60A  )  6JOK  (X-ray  3.80A  )  6JOL  (X-ray  1.90A  )  7LBF  (EM  2.80A  )  7RAM  (EM  3.43A  ) 
DBSNP rs36035373  rs55865821  rs35597368  rs121908589  rs121908586  rs1057519700  rs34392012  rs121908585  rs121913265  rs121908588  rs779173667  rs376544204 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664};
Single-pass type I membrane protein {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664}. Cell projection, cilium {ECO:0000250|UniProtKB:P26618}. Golgi apparatus {ECO:0000250|UniProtKB:P26618}.
Mouse PG classificationNA
click here to return to the previous page