| Gene Information | |
|---|---|
| Gene Name | MCM5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 734 |
| Protein Names | DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000100297 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P33992 |
| Gene Card | MCM5 |
| Uniprot ID | P33992 |
| Pfam | PF00493; PF17855; PF14551; PF17207 |
| In ASD | no |
| Allosteric Prediction | yes (0.432295563) |
| Ortholog in Animals | Alpaca_ MCM5 ( ortholog_one2one ) Dog_ MCM5 ( ortholog_one2one ) GuineaPig_ MCM5 ( ortholog_one2one ) Macaque_ MCM5 ( ortholog_one2one ) Mouse_ Mcm5 ( ortholog_one2one ) Pig_ MCM5 ( ortholog_one2one ) Rat_ Mcm5 ( ortholog_one2one ) Rabbit_ MCM5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MCMDC2, MCM4, MCM6, MCM9, MCM2, MCM8, MCM7, MCM3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.093224(Chimpanzee);0.150756(Mouse);0.169412(Rat);0.140091(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6XTX (EM 3.29A ) 6XTY (EM 6.77A ) 7PFO (EM 3.20A ) 7PLO (EM 2.80A ) |
| DBSNP | rs2307334 rs2307340 rs2230933 rs1131692169 |
| Subcellular location [CC] | Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000305|PubMed:35585232}. |
| Mouse PG classification | NA |
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