| Gene Information | |
|---|---|
| Gene Name | MAPK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 360 |
| Protein Names | Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) |
| Target Name | extracellular signal-regulated kinase 2 |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000100030 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P28482 |
| Gene Card | MAPK1 |
| Uniprot ID | P28482 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (1.553761475) |
| Ortholog in Animals | Alpaca_ MAPK1 ( ortholog_one2one ) Dog_ MAPK1 ( ortholog_one2one ) GuineaPig_ MAPK1 ( ortholog_one2one ) Macaque_ MAPK1 ( ortholog_one2one ) Mouse_ Mapk1 ( ortholog_one2one ) Pig_ MAPK1 ( ortholog_one2one ) Rat_ Mapk1 ( ortholog_one2one ) Rabbit_ MAPK1 ( ortholog_one2one ) |
| Ohnologs | MAPK3 |
| Paralogs | MAPK8, MAPK10, MAPK6, MAPK12, MAPK13, SRPK1, SRPK3, MAPK4, NLK, MAPK14, MAPK3, MOK, MAPK11, MAK, MAPK15, MAPK7, SRPK2, MAPK9, CILK1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.193112(Chimpanzee);0.192895(Mouse);NULL(Rat);0.147556(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1PME (X-ray 2.00A ) 1TVO (X-ray 2.50A ) 1WZY (X-ray 2.50A ) 2OJG (X-ray 2.00A ) 2OJI (X-ray 2.60A ) 2OJJ (X-ray 2.40A ) 2Y9Q (X-ray 1.55A ) 3D42 (X-ray 2.46A ) 3D44 (X-ray 1.90A ) 3I5Z (X-ray 2.20A ) 3I60 (X-ray 2.50A ) 3SA0 (X-ray 1.59A ) 3TEI (X-ray 2.40A ) 3W55 (X-ray 3.00A ) 4FMQ (X-ray 2.10A ) 4FUX (X-ray 2.20A ) 4FUY (X-ray 2.00A ) 4FV0 (X-ray 2.10A ) 4FV1 (X-ray 1.99A ) 4FV2 (X-ray 2.00A ) 4FV3 (X-ray 2.20A ) 4FV4 (X-ray 2.50A ) 4FV5 (X-ray 2.40A ) 4FV6 (X-ray 2.50A ) 4FV7 (X-ray 1.90A ) 4FV8 (X-ray 2.00A ) 4FV9 (X-ray 2.11A ) 4G6N (X-ray 2.00A ) 4G6O (X-ray 2.20A ) 4H3P (X-ray 2.30A ) 4H3Q (X-ray 2.20A ) 4IZ5 (X-ray 3.19A ) 4IZ7 (X-ray 1.80A ) 4IZA (X-ray 1.93A ) 4N0S (X-ray 1.80A ) 4NIF (X-ray 2.15A ) 4O6E (X-ray 1.95A ) 4QP1 (X-ray 2.70A ) 4QP2 (X-ray 2.23A ) 4QP3 (X-ray 2.60A ) 4QP4 (X-ray 2.20A ) 4QP6 (X-ray 3.10A ) 4QP7 (X-ray 2.25A ) 4QP8 (X-ray 2.45A ) 4QP9 (X-ray 2.00A ) 4QPA (X-ray 2.85A ) 4QTA (X-ray 1.45A ) 4QTE (X-ray 1.50A ) 4XJ0 (X-ray 2.58A ) 4ZXT (X-ray 2.00A ) 4ZZM (X-ray 1.89A ) 4ZZN (X-ray 1.33A ) 4ZZO (X-ray 1.63A ) 5AX3 (X-ray 2.98A ) 5BUE (X-ray 2.40A ) 5BUI (X-ray 2.12A ) 5BUJ (X-ray 1.85A ) 5BVD (X-ray 1.90A ) 5BVE (X-ray 2.00A ) 5BVF (X-ray 1.90A ) 5K4I (X-ray 1.76A ) 5LCJ (X-ray 1.78A ) 5LCK (X-ray 1.89A ) 5NGU (X-ray 2.74A ) 5NHF (X-ray 2.14A ) 5NHH (X-ray 1.94A ) 5NHJ (X-ray 2.12A ) 5NHL (X-ray 2.07A ) 5NHO (X-ray 2.24A ) 5NHP (X-ray 1.99A ) 5NHV (X-ray 2.00A ) 5V60 (X-ray 2.18A ) 5V61 (X-ray 2.20A ) 5V62 (X-ray 1.90A ) 5WP1 (X-ray 1.40A ) 6D5Y (X-ray 2.86A ) 6DMG (X-ray 2.20A ) 6G54 (X-ray 2.05A ) 6G8X (X-ray 1.76A ) 6G91 (X-ray 1.80A ) 6G92 (X-ray 1.99A ) 6G93 (X-ray 1.67A ) 6G97 (X-ray 1.90A ) 6G9A (X-ray 1.91A ) 6G9D (X-ray 1.80A ) 6G9H (X-ray 1.73A ) 6G9J (X-ray 1.98A ) 6G9K (X-ray 1.94A ) 6G9M (X-ray 1.86A ) 6G9N (X-ray 1.76A ) 6GDM (X-ray 1.91A ) 6GDQ (X-ray 1.86A ) 6GE0 (X-ray 1.82A ) 6GJB (X-ray 1.82A ) 6GJD (X-ray 1.58A ) 6NBS (X-ray 1.90A ) 6OPG (X-ray 2.90A ) 6OPH (X-ray 2.40A ) 6OPI (X-ray 3.00A ) 6Q7K (X-ray 1.84A ) 6Q7S (X-ray 1.73A ) 6Q7T (X-ray 1.60A ) 6QA1 (X-ray 1.58A ) 6QA3 (X-ray 1.57A ) 6QA4 (X-ray 1.60A ) 6QAG (X-ray 2.07A ) 6QAH (X-ray 1.58A ) 6QAL (X-ray 1.57A ) 6QAQ (X-ray 1.58A ) 6QAW (X-ray 1.84A ) 6RQ4 (X-ray 1.96A ) 6SLG (X-ray 1.33A ) 7AUV (X-ray 1.76A ) 7E73 (X-ray 2.28A ) 7E75 (X-ray 2.48A ) 7NQQ (X-ray 1.94A ) 7NQW (X-ray 1.77A ) 7NR3 (X-ray 1.90A ) 7NR5 (X-ray 1.77A ) 7NR8 (X-ray 1.63A ) 7NR9 (X-ray 1.91A ) 7OPM (X-ray 2.45A ) 7W5O (X-ray 2.35A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Nucleus {ECO:0000269|PubMed:32721402}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm {ECO:0000269|PubMed:32721402}. Membrane, caveola {ECO:0000250|UniProtKB:P63086}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P63085}. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. {ECO:0000250}. |
| Mouse PG classification | NA |
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