| Gene Information | |
|---|---|
| Gene Name | MCM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 719 |
| Protein Names | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000073111 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P33993 |
| Gene Card | MCM7 |
| Uniprot ID | P33993 |
| Pfam | PF00493; PF17855; PF14551; PF17207 |
| In ASD | no |
| Allosteric Prediction | yes (0.235572304) |
| Ortholog in Animals | Alpaca_ MCM2 ( ortholog_one2one ) Dog_ MCM2 ( ortholog_one2one ) GuineaPig_ MCM2 ( ortholog_one2one ) Macaque_ MCM2 ( ortholog_one2one ) Mouse_ Mcm2 ( ortholog_one2one ) Pig_ MCM2 ( ortholog_one2one ) Rat_ Mcm2 ( ortholog_one2one ) Rabbit_ MCM2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MCMDC2, MCM4, MCM9, MCM8, MCM5, MCM6, MCM7, MCM3 |
| Tissue | brain, testis |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6XTX (EM 3.29A ) 6XTY (EM 6.77A ) 7PFO (EM 3.20A ) 7PLO (EM 2.80A ) |
| DBSNP | rs2307348 rs2070215 rs2307347 |
| Subcellular location [CC] | Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000305|PubMed:35585232}. |
| Mouse PG classification | NA |
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